The Anti-Mullerian Hormone Levels In Polycystic Ovary Syndrome And Its Relation To Body Mass Index | ||
Iraqi Postgraduate Medical Journal | ||
Volume 22, Issue 4, October 2023, Pages 473-480 PDF (250.2 K) | ||
Document Type: Review Article | ||
DOI: 10.52573/ipmj.2023.182305 | ||
Authors | ||
Muna Sabah Jabar1; Abdulrazak H. Alnakash* 2; Saba Kamal Al-Jubouri3 | ||
1Obstetrics and Gynecology dept., Al-Elwiya Maternity Teaching Hospital, Baghdad, Iraq | ||
2Alkindy College of Medicine, University of Baghdad, Al-Elwiya Maternity Teaching Hospital, Baghdad, Iraq | ||
3Family Medicine, Nutrition Research Institute Public Health Directorate, Baghdad, Iraq | ||
Abstract | ||
BACKGROUND: Anti-mullerian hormone level reflects the ovarian follicular reserve and considered as sensitive marker of ovarian aging. Although the ultimate pathogenesis of polycystic ovary syndrom remains obscure, the distinictive feature is a failure of follicular maturation resulting in anovulation and accumulation of pre-antral and small antral follicles which contribute significantly to the production of anti-mullerian hormone. OBJECTIVE: To evaluate the anti-mullerian hormone levels in polycystic ovary syndrome women and to explore its relation with body mass index. STUDY DESIGN: Cross section study. Setting: Department of Gynecology and Obstetrics at Al-Elwiya Maternity Teaching Hospital. MATERIALS AND METHODS: One hunderd women suffering from polycystic ovary syndrom (18-37 years old) were included in the study and arranged in three groups according to their body mass index: first group, 30 of them, were having normal body weight (body mass index 18.5 to 24.9kg/m2) and second group, 59 participants with body mass index 25 to 29.9kg/m2 and third group, 11 women, their body mass index ≥ 30kg/m2. Blood sample was collected from them after taking a detailed history and assessment according to the questioner form and the results were compared among the groups. RESULTS: Increase in body mass index is found to be accompanied with decrease in anti-mullerian hormone levels (P <0.05), with mean anti-mullerian hormone level significantly decreases as body mass shifts up from normal to overweight to obesity (8.5, 6.4 & 4.4 ng/mL respectively) (P <0.05). Anti-mullerian hormone level did not significantly correlate with age of those women (P >0.05). CONCLUSION: An inverse correlation had been found between anti-mullerian hormone levels and body mass index in women with polycystic ovary syndrome. | ||
Keywords | ||
Anti-mullerian hormone; Body mass index; polycystic ovary syndrome | ||
References | ||
13. Mei-Jou Chen,Wei-Shiung Yang, Chi-Ling Chen,et al,,.The relation between anti-mullerian hormone, androgen and insulin resistance on the number of antral follicles in women with polycystic ovary syndrome. Hum Reprod.2008; 23:952-57.
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