Hadi, N., Al-Ghany, H. (2023). The Role of Serum Adropin Level in Diagnosis of Gestational Diabetes Mellitus. Alustath, 22(4), 426-431. doi: 10.52573/ipmj.2023.182287
Nadia Sabah Hadi; Hala Abd Al-Ghany. "The Role of Serum Adropin Level in Diagnosis of Gestational Diabetes Mellitus". Alustath, 22, 4, 2023, 426-431. doi: 10.52573/ipmj.2023.182287
Hadi, N., Al-Ghany, H. (2023). 'The Role of Serum Adropin Level in Diagnosis of Gestational Diabetes Mellitus', Alustath, 22(4), pp. 426-431. doi: 10.52573/ipmj.2023.182287
Hadi, N., Al-Ghany, H. The Role of Serum Adropin Level in Diagnosis of Gestational Diabetes Mellitus. Alustath, 2023; 22(4): 426-431. doi: 10.52573/ipmj.2023.182287

The Role of Serum Adropin Level in Diagnosis of Gestational Diabetes Mellitus

Iraqi Postgraduate Medical Journal
Volume 22, Issue 4, October 2023, Pages 426-431    PDF (360.42 K)
Document Type: Review Article
DOI: 10.52573/ipmj.2023.182287
Authors
Nadia Sabah Hadi* 1; Hala Abd Al-Ghany2
1AL-Karkh Maternity Hospital, Baghdad, Iraq
2AL Yarmouk Teaching Hospital, Baghdad, Iraq
Abstract
BACKGROUND:
In pregnancy, Gestational Diabetes Mellitus is considered as intolerance to carbohydrate which discovered in pregnancy. It is a glucose metabolism abnormality associated with long and short-term morbidities that could affecting both of the offspring and mother such as shoulder dystocia, preeclampsia or hypertension.
OBJECTIVE:
To evaluate the level of serum adropin in pregnant ladies with Gestational Diabetes Mellitus (GDM) in comparison with that of normal euglycemic pregnant patient.
METHODS:
At National Diabetes Center and AL-Yarmouk teaching hospital, a case-control study was done for the period from January 2020 to October 2020. Forty pregnant ladies with Gestational Diabetes Mellitus (cases) and fifty healthy pregnant ladies (controls) were involved. Lipid concentration and serum adropin were evaluated between 24th-28th weeks of pregnancy for the two groups. The results were compared between them using independent sample t-test.
RESULTS:
Serum adropin was significantly correlated with maternal age, and fasting blood sugar and 2-hour blood glucose measurement after subjecting them to 75-gram Oral Glucose Tolerance Test (p-value: 0.004, 0.001, 0.001) respectively but, serum adropin was significantly negatively associated with Gestational Diabetes Mellitus (AUC: 0.927, PV=0.001, 95%CI: 0.860-0.964) the cutoff point of 38.05 with sensitivity of72.5% and specifity of 98% was considered as the most accurate point of adropin concentration for diagnosis of Gestational Diabetes Mellitus.
CONCLUSION:
Low level of serum adropin is independent diagnostic factor for Gestational Diabetes Mellitus.
 
Keywords
  Adropin hormone; Gestational Diabetes Mellitus; oral glucose tolerance test
References
  1. American Diabetic Association Classification and diagnosis of diabetes mellitus· Diabetic care 2015; 38(suppl):S8- S16· http://doi·org/10·2337/dc15-2005
  2. Williams D· Medical complications of pregnancy· In: Kenny L, Myers J, E.Ds. Obstetrics by Ten Teacher: Cleveland, 2017: 306-309· http://doi·org/10·1201/9781315382401
  3. F· Gary Cunni Butler AA, Tam CS, Stanhope KL, Wolfe BM, Ali MR, O'Keeffe M, St-Onge MP, Ravussin E, Havel PJ. Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. The Journal of Clinical Endocrinology & Metabolism. 2012;97:3783-91.
  4. ngham, Kenneth J, Steven L·, et al· Gestational diabetes mellitus· Williams O BSTETRICS, 24th edition Mc Graw-Hill Edition ·2014; 57: 1136-37 ·
  5. Catalano PM. Obesity, insulin resistance and pregnancy outcome. Reproduction (Cambridge, England). 2010 ;140 :365.
  6. Ganesh‐Kumar K, Zhang J, Gao S, Rossi J, McGuinness OP, Halem HH, Culler MD, Et.al. Adropin deficiency is associated with increased adiposity and insulin resistance. Obesity. 2012;20:1394-402.
  7. Yong, H. Y., et al. independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus. Sci Rep 10, 8486 (2020). https://doi.org/10.1038/s41598-020-65251-2.
  8. Han, Y., Tong, M., Jin, L. et al. maternal age at pregnancy and risk for gestational diabetes mellitus among Chinese women with singleton pregnancies. International journal of diabetes in developing countries (2020). https://doi.org/10.1007/s 13410-020-00859-8
  9. Keith Edmonds CL· Dewhurset, s Textbook of Obstetrics and Gynaecology· 9th Ed· Balen A, editor· Blackwell Publishing Ltd: Sarah N· Ali and Anne Dornhorst Ltd 2018;9:100
  10. Aydin S, Kuloglu T, Aydin S, Eren MN, Yilmaz M, Kalayci M, Et.al. Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes. Molecular and cellular biochemistry. 2013;380:73-81.
 

  1. Butler AA, Tam CS, Stanhope KL, Wolfe BM, Ali MR, O'Keeffe M, St-Onge MP, Ravussin E, Havel PJ. Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. The Journal of Clinical Endocrinology & Metabolism. 2012;97:3783-91.
  2. Filip A. Dabrowski., et al.first and third trimester serum concentration of adropin and copeptin in gestational diabetes mellitus and normal pregnancy, department of experimental and clinical physiology, laboratory of center for preclinical research. Medical university of Warsaw, banacha st. 1b, 02-097 Warsaw, Poland, e-mail: gondek@wum.edu.pl
  3. Abu-Heija AT, Al-Bash MR, Al-Kalbani MA. Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus. Journal of Taibah University medical sciences. 2017;12:338-42.
  4. Chang .J.B., et al. Relationship between plasma adropin levels and body composition and lipid characteristics amongst young adolescents in Taiwan. Jan-feb 2018;12(supple2):101-107. Doi:10.1016/j.orcp.2017.03.001.
  5. A., et al. association between serum adropin level and gestational diabetes mellitus; a case-control study, gynecological endocrinology, 31:12:939-41, http//dx, doi, org/ 10.3109/09513590.2015.1081681
  6. Celik E, Yilmaz E, Celik O, Ulas M, Turkcuoglu I, Karaer A, Simsek Y, Minareci Y, Aydin S. Maternal and fetal adropin levels in gestational diabetes
  7. Zang, H, et al. serum adropin levels are decreased in Chinese type 2 diabetic patients and negatively correlated with body mass index, 2018, p. 685-691.doi: https://doi.org/10.1507/Ej 18-0060
  8. Journal of perinatal medicine. 2013;41:375-80.
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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