Assessment of Procalcitonin Level in Obese Patients with Insulin Resistance | ||
| The Medical Journal of Basrah University | ||
| Volume 41, Issue 2, December 2023, Pages 188-195 PDF (505.64 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2023.144817.1170 | ||
| Authors | ||
| Ali Jassim Turki* 1; Jamal Ahmed barry2; Hussein Ali Nwayyir Al-Hassan3 | ||
| 1college of Medicine | ||
| 2Department of Biochemistry, Faculty of Medicine, University of Basrah | ||
| 3Department of Medicine, Faculty of Medicine, University of Basrah | ||
| Abstract | ||
| Abstract: Background: Obesity is a widespread health issue worldwide, marked by long-lasting, low-level inflammation and resistance to insulin. Procalcitonin (PCT) has been recognized as a probable indicator of inflammation linked to obesity, given that high levels of PCT in the blood are strongly associated with measures of fatness and insulin resistance. Nevertheless, the exact role of PCT in insulin resistance remains uncertain. Objectives: The study aims to provide insights into the role of PCT in obesity-related inflammation and evaluate its potential as a diagnostic tool for insulin resistance. Methods: The study included 120 subjects with obesity and insulin resistance, and 80 control group. The study also included anthropometric measurements (BMI, WC, and blood pressure) and laboratory tests (fasting serum insulin, fasting serum glucose, and plasma procalcitonin). Results: In the study, 120 patients diagnosed with obesity were compared to 80 controls. The research found that the average level of procalcitonin (PCT) was significantly higher in obese patients (P <0.05) when compared to the control group. Specifically, the mean PCT level in obese patients was 0.122±0.168 ng/ml, while in controls, it was 0.086±0.0047 ng/ml. The analysis also showed a significant correlation between PCT and insulin resistance, as measured by HOMA-IR, with a Pearson correlation coefficient of 0.187 and a (P-value 0.040). Conclusion: The study found that the mean level of procalcitonin (PCT) was significantly higher in patients with obesity and insulin resistance compared to controls. | ||
| Keywords | ||
| Procalcitonin; Insulin Resistance; Obesity | ||
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