Serum and urinary transforming growth factor beta 1 (TGF-β1) as biochemical marker in diabetic nephropathy patients | ||
| The Medical Journal of Basrah University | ||
| Volume 41, Issue 2, December 2023, Pages 177-187 PDF (568.13 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2023.144482.1167 | ||
| Authors | ||
| Ali Hasan Jasim* 1; Nazar S. Haddad2; Nassar Taha Alibrahim3 | ||
| 1Department of Biochemistry, Faculty of Medicine, University of Basrah | ||
| 2The University of Basrah, College of Medicine, | ||
| 3Faiha Specialized Diabetes, Endocrine and Metabolism Center, Basrah, Iraq. | ||
| Abstract | ||
| Abstract Background: Diabetes mellitus is a chronic metabolic illness that causes hyperglycaemia. This hyperglycaemia may be the consequence of a malfunction in insulin synthesis, insulin action, or both. DM can raise the risk for the development of microvascular as well as macrovascular problems. An increase in oxidative stress and inflammation are two of the hallmarks of diabetes, which is recognized as a disorder in and of itself. TGF-beta is a member of the TGF-beta subfamily, which is a part of the TGF-beta superfamily Methods: The current research comprised a total of 130 individuals, all were placed into three primary groups ; 50 diabetic patients without nephropathy,50 diabetic patients with nephropathy, and 30 persons in good health who were the same age and gender as the patients being studied,50 urine sample has been taken from participants in order to measure the concentrations of the parameters, the standard procedures and techniques were used. Results: The results of the present study revealed that the mean value of serum TGF β1was significantly higher in diabetic patients without nephropathy and diabetic patients with nephropathy (40.19±3.56ng ̷ ml),(51.21±5.20ng ̷ ml) respectively as compared to controls (24.80±3.51 ng ̷ ml) with a high significant difference (P <0.01). The level of TGF β1 showed a positive correlation in the study population with fasting blood sugar (r=0.273, P=0.006). Conclusion: The main finding of the present study that there was a significant difference (p<0.05) between serum TGF-β1 in diabetic patients with nephropathy, diabetic patients without nephropathy and controls. | ||
| Keywords | ||
| Type 2 Diabetes mellitus; ،nephropathy; ،TGF-β1; ؛; ،Cystatin-C | ||
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