Effect of Tocotrienols Derived from Annatto on Lipid Profile and Some Adipokine Hormones in Rats Fed a High-Fat Diet | ||
| Basrah Journal of Veterinary Research | ||
| Volume 22, Issue 4, December 2023, Pages 75-87 PDF (454.58 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bjvetr.2023.144656.1049 | ||
| Authors | ||
| Eman hanash Rahi* 1; Nameer A. Khudhair2 | ||
| 11- Department of Veterinary Physiology, College of Veterinary Medicine, University of Basrah, Basrah, Iraq. 2- Department of basic Sciences, College of Nursing, University of Basrah, Basrah, Iraq. | ||
| 2Department of Veterinary Public health, College of Veterinary Medicine, University of Basrah, Basrah, Iraq. | ||
| Abstract | ||
| Obesity is a metabolic condition that causes people to develop a variety of diseases and has emerged as a serious global public-health problem. Tocotrienol, a member of the vitamin E family that comes from the annatto bean (Bixa orellana), is special in that it doesn't contain alpha-tocopherol and instead mostly consists of delta-tocotrienol (approximately 90%) and gamma-tocotrienol (about 10%). This investigation aimed to ascertain whether annatto tocotrienol could improve certain biochemical indicators and metabolic hormones in male rats fed a high-fat diet. Eighteen adult male rats in total were split into three groups randomly (6 for each). Control group was given a diet low in fat (LF 10 % kcal from fat), High fat diet (HFD) group was fed with high fat diet (HF 60 % kcal from fat), And high fat diet with tocotrienol (HFDT) group was fed with high fat diet additive tocotrienol (60 mg/kg) dissolved in olive oil (1ml/kg) for 12 weeks. Tocotrienol treatment led to a significant decrease in total protein and globulin compared with the high-fat diet group and it significantly increased HDL-C compared with rats fed on a high-fat diet and control groups. While, tocotrienols significantly reduced the level of LDL and insulin hormone in the High fat diet plus tocotrienols group compared to the other groups. | ||
| Keywords | ||
| tocotrienols; high-fat diet; leptin; adiponectin | ||
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