Clinical Implication of Serum and Immunohistochemistry Expression of Human Placental Growth Hormone in Ectopic Pregnancy | ||
Iraqi Postgraduate Medical Journal | ||
Article 13, Volume 22, Issue 3, July 2023, Pages 319-324 PDF (306.65 K) | ||
DOI: 10.52573/ipmj.2023.181196 | ||
Authors | ||
Nour Fawzi Shaheed* 1; Maha Mohamed Jasim Al-Bayati2 | ||
1Martyr Dhari al- Fayad Hospital, Al-Husseiniya, Baghdad, Iraq | ||
2Gynecology and Obstetrics, retired professor | ||
Abstract | ||
BACKGROUND: Ectopic pregnancy causes major maternal morbidity and mortality. Human Placental growth hormone shows a non-pulsatile secretion pattern and short serum half-life making it of major advantage compared to the standard marker human chorionic gonadotropin. OBJECTIVE: To evaluate the clinical implication of serum human placental growth hormone variant and immunohistochemistry as a possible biomarker for the course of ectopic pregnancy. PATIENTS AND METHODS: This is a cross sectional study carried out in the department of Obstetrics and Gynecology of Al- Yarmouk Teaching Hospital for the period from January 2020 to October 2020, It includes 50 pregnant women in first trimester with confirmed ectopic pregnancy, maternal serum β -human chorionic gonadotrophin titer was measured and human placental growth hormone variant level was analyzed for each patient using enzyme-linked immunosorbent assay and tissue specimen were taken from serum human placental growth hormone variant negative and positive cases and examined by immunohistochemistry. RESULTS: Serum human placental growth hormone variant was shown to be positive in 28 cases of ectopic pregnancy and negative in 22 cases, β-human chorionic gonadotropin levels were significantly higher in the serum of the patient with human placental growth hormone variant positive group (p-value = 0.001). Serum human placental growth hormone variant was positive in all specimens of cases examined by immunohistochemistry even in serum negative cases. CONCLUSION: Human Placental growth hormone was shown to be present both in serum and tissue of ectopic pregnancy patients. Its short half-life makes it of a great clinical advantage as a biomarker for ectopic pregnancy course and monitoring response to treatment. | ||
Keywords | ||
β-human chorionic gonadotropin; Ectopic pregnancy; Human placental growth hormone variant | ||
References | ||
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