ABSTRACT:
BACKGROUND:
Alopecia areata is an inflammatory, non-scaring type of hair loss. Microneedling is a new therapeutic procedure used in dermatology. It facilitates the absorption of topical therapies across the epidermis.
AIM OF STUDY:
Evaluating the efficacy of Microneedling combined with clobetasol propionate 0.05% cream versus clobetasol propionate 0.05% cream alone in treatment of alopecia areata.
PATIENTS AND METHODS:
This study was carried out on 20 patients and the total number of patches was 99. In the same patient, at least 2 patches were selected to be treated as group A or B; so, the 99 patches were divided in to two groups.
Group A: Microneedling combined with clobetasol propionate 0.05% cream: 51 patches (from 20 patients) were treated using a dermapen devise. The cream was applied before and after microneedling and a total of four sessions were done at 2 weeks interval, then patients were seen after 2 weeks from the last session for follow up. Group B: clobetasol propionate 0.05% cream alone: 48 patches (from the same 20 patients) were treated, the cream was applied twice daily with gentle massage for 3-5 minutes for 8 weeks duration. Patients were seen at 2 weeks interval.
RESULTS:
At 8th week visit: the response to treatment in group A was seen in 58.8% of the patches and 63.3% of them showed complete coarse hair regrowth while in group B, the response to treatment was seen in 58.3% of the patches and 32.1% of them showed complete coarse hair regrowth. When two groups were compared regarding complete hair regrowth there was statistically significant difference.
CONCLUSION:
Combination of Microneedling with clobetasol propionate 0.05% cream is a promising, safe and easy to perform technique in the treatment of alopecia areata
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