Jibroo, R., Mustafa, Y., Al-Shakarchi, W. (2023). Coumarin-Based Derivatives: A Review of Their Synthetic Routes, Reactivity, and Biomedical Attributes. Alustath, 20(2), 133-151. doi: 10.33899/iphr.2023.142709.1054
Rana Naeem Jibroo; Yasser Fakri Mustafa; Wejdan Al-Shakarchi. "Coumarin-Based Derivatives: A Review of Their Synthetic Routes, Reactivity, and Biomedical Attributes". Alustath, 20, 2, 2023, 133-151. doi: 10.33899/iphr.2023.142709.1054
Jibroo, R., Mustafa, Y., Al-Shakarchi, W. (2023). 'Coumarin-Based Derivatives: A Review of Their Synthetic Routes, Reactivity, and Biomedical Attributes', Alustath, 20(2), pp. 133-151. doi: 10.33899/iphr.2023.142709.1054
Jibroo, R., Mustafa, Y., Al-Shakarchi, W. Coumarin-Based Derivatives: A Review of Their Synthetic Routes, Reactivity, and Biomedical Attributes. Alustath, 2023; 20(2): 133-151. doi: 10.33899/iphr.2023.142709.1054

Coumarin-Based Derivatives: A Review of Their Synthetic Routes, Reactivity, and Biomedical Attributes

Iraqi Journal of Pharmacy
Volume 20, Issue 2, December 2023, Pages 133-151    PDF (1.55 M)
Document Type: Review Paper
DOI: 10.33899/iphr.2023.142709.1054
Authors
Rana Naeem Jibroo* 1; Yasser Fakri Mustafa2; Wejdan Al-Shakarchi1
1Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq
2Pharmaceutical Chemistry Department, College of Pharmacy, Mosul University, Nineveh, Iraq
Abstract
Background: Coumarin-based derivatives (Cou-Ds) are one of the most important types of heterocycles, with a wide range of uses in synthetic and medicinal chemistry. Cou-Ds have interested researchers due to their wide range of biomedical potential and application as valuable synthetic scaffolds, which have been instrumental in the creation of coumarin chemistry. Cou-Ds are a unique class of bioactive candidates with novel therapeutic attributes due to their bacteriostatic, antifungal, antioxidant, anticancer, antidepressant, and other pharmacological properties. In addition to their biomedical uses, the literature illustrates the uses of Cou-Ds from a material point of view, such as those in food additives, fragrances, beauty products, optical brighteners, and would disperse fluorescent and laser dyes. Numerous optical purposes using Cou-Ds have been thoroughly investigated. A wide range of natural sources and newly created Cou-Ds are being isolated or produced at a growing rate. The procedures of synthesis and therapeutic uses of Cou-Ds in the treatment of various illnesses were critically found in many published papers. Aim: The aim of this review article is to highlight the most up-to-date information about Cou-Ds and clarify the various natural sources, synthetic strategies, reactions, biological activity, and different pharmaceutical applications of Cou-Ds. Conclusion: From the collected and discussed reviewing information, the authors concluded that the Cou-Ds can open the drug development door for producing more potent, biosafe medicines.
Keywords
Coumarin-based derivative; Synthetic pathways; Biomedical potential; Natural sources; Antimicrobial; Antitumor; Antioxidant
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