Waheed, N., Abdulaziz, N., Hammodi, S., Mustafa, Y. (2023). Thionyl Chloride: A Catalyst of Synthetic Chemical Interest. Alustath, 20(2), 111-125. doi: 10.33899/iphr.2023.142271.1053
Noor Ahmed Waheed; Noora Thamer Abdulaziz; Sawsan Hasan Hammodi; Yasser Fakri Mustafa. "Thionyl Chloride: A Catalyst of Synthetic Chemical Interest". Alustath, 20, 2, 2023, 111-125. doi: 10.33899/iphr.2023.142271.1053
Waheed, N., Abdulaziz, N., Hammodi, S., Mustafa, Y. (2023). 'Thionyl Chloride: A Catalyst of Synthetic Chemical Interest', Alustath, 20(2), pp. 111-125. doi: 10.33899/iphr.2023.142271.1053
Waheed, N., Abdulaziz, N., Hammodi, S., Mustafa, Y. Thionyl Chloride: A Catalyst of Synthetic Chemical Interest. Alustath, 2023; 20(2): 111-125. doi: 10.33899/iphr.2023.142271.1053

Thionyl Chloride: A Catalyst of Synthetic Chemical Interest

Iraqi Journal of Pharmacy
Volume 20, Issue 2, December 2023, Pages 111-125    PDF (713.19 K)
Document Type: Review Paper
DOI: 10.33899/iphr.2023.142271.1053
Authors
Noor Ahmed Waheed1; Noora Thamer Abdulaziz* 2; Sawsan Hasan Hammodi1; Yasser Fakri Mustafa1
1Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq
2Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq
Abstract
Background: Particularly developed ingredients that are easily manufactured and utilized for additional exploitation are used in organic synthetic chemistry. Thionyl chloride serves as a significant illustration of such an ingredient. The usefulness of which has been discussed in a huge number of peer-reviewed papers. Aim: The literature that has been released since the previous assessment in 1980, which mainly focused on the responses of active methylene compounds, is where this review places its focus. In the present overview, we also discuss O- and N-nucleophiles. For the most part, patents have been disregarded in this analysis in order to keep it feasible. Conclusion: The authors concluded that SOCl2 has a variety of behaviors, including the ability to function as an initiator or a reactant, which makes it essential for the synthesis of many chemically reactive intermediates and final products. Additionally, SOCl2 can speed up and reduce the duration of traditionally long reactions, thereby raising its importance.
Keywords
Thionyl chloride; Coupling reaction; Chalcone; Amine; Alcohol
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