Oxidation: The Most Common Pathway for the Pro-drugs Bio Precursors Activation | ||
| Rafidain Journal of Science | ||
| Volume 32, Issue 3, September 2023, Pages 41-47 PDF (920.15 K) | ||
| Document Type: Review Paper | ||
| DOI: 10.33899/rjs.2023.180275 | ||
| Authors | ||
| Shakir M. Saied1; Mohanad Yakdhan Saleh2; Salim J. Mohammed3 | ||
| 1Department of Pharmacy/ Al-Noor University College/ Mosul/ Iraq | ||
| 2Dept. of Chem., College of Education for pure Scienceو Mosul University, Mosul,IRAQ | ||
| 3Department of Chemistry/ College of Science/ University of Mosul | ||
| Abstract | ||
| Oxidation of inactive prodrug (that their mode of action is not via linkage carrier, but occur through modification of their molecules which are called the bio precursor) to active parent drug design is generally via the methods modification strategies that aim to improve the physicochemical and pharmacological properties of drugs such as increases bioavailability, water solubility and/or duration of action. The goal of this review is to study the up-to-date advances in the prodrug’s oxidative activation such as N- and O- oxidative dealkylation, oxidative deamination, N-oxidative and S-oxidative important strategies to produce the parents’ active drugs. Oxidation reactions are of great importance and most cancerous diseases begin with these reactions. | ||
| Keywords | ||
| prodrug; oxidative activation; linkage carrier; drug bioavailability | ||
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