Bashir, M., Oglah, M., Mustafa, Y., Mahmood, A. (2023). The Influence of Dioxolane Ring Conjugates on Biological Activities: A Review Study. Alustath, 20(2), 99-110. doi: 10.33899/iphr.2023.142073.1051
Moath Kahtan Bashir; Mahmood Khudhayer Oglah; Yasser Fakri Mustafa; Ahmed Abdul-jabbar Mahmood. "The Influence of Dioxolane Ring Conjugates on Biological Activities: A Review Study". Alustath, 20, 2, 2023, 99-110. doi: 10.33899/iphr.2023.142073.1051
Bashir, M., Oglah, M., Mustafa, Y., Mahmood, A. (2023). 'The Influence of Dioxolane Ring Conjugates on Biological Activities: A Review Study', Alustath, 20(2), pp. 99-110. doi: 10.33899/iphr.2023.142073.1051
Bashir, M., Oglah, M., Mustafa, Y., Mahmood, A. The Influence of Dioxolane Ring Conjugates on Biological Activities: A Review Study. Alustath, 2023; 20(2): 99-110. doi: 10.33899/iphr.2023.142073.1051

The Influence of Dioxolane Ring Conjugates on Biological Activities: A Review Study

Iraqi Journal of Pharmacy
Volume 20, Issue 2, December 2023, Pages 99-110    PDF (1009.86 K)
Document Type: Review Paper
DOI: 10.33899/iphr.2023.142073.1051
Authors
Moath Kahtan Bashir* ; Mahmood Khudhayer Oglah; Yasser Fakri Mustafa; Ahmed Abdul-jabbar Mahmood
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq
Abstract
Background: The problem of drug side effects necessitates the design, synthesis, and development of novel therapeutic agents that possess high activity with minimal side effects. According to the structure-activity relationship, the dioxolane moiety is found in many natural therapeutic agents and plays an important role in their medical action. Synthetic dioxolane conjugates have been studied in a variety of biological fields, including cytotoxicity, antibacterial, antifungal, antiviral, antioxidant, and anti-inflammatory activity, and have demonstrated a distinct potency that encourages further research in this mode. Aim: This review highlights the most recent studies on dioxolane ring conjugates in various biological fields as a promising bioactive heterocyclic scaffold. Conclusion: The hydrogen bonding of the oxygen atoms in this heterocyclic ring with the target site may be responsible for the enhanced ligand-target interactions and improved bioactivity.
Keywords
Dioxolane; Heterocyclic; Antibacterial; Antifungal; Antiviral; Cytotoxic
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