The Impact of Severe Hypertriglyceridemia on Glycosylated Hemoglobin Test in Type 2 Diabetes Mellitus | ||
| The Medical Journal of Basrah University | ||
| Article 9, Volume 40, Issue 2, June 2022, Pages 163-170 PDF (506.98 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2023.134409.1118 | ||
| Author | ||
| Ali Emad Salim* | ||
| Al-Fayhaa Teaching Hospital, Basrah, Iraq | ||
| Abstract | ||
| Abstract Background: Although the glycosylated hemoglobin (HbA1c) test is a valid test for diabetes diagnosis and evaluation of glycemic control, many factors are known to affect the results of the HbA1c test and make it reflects a false image of the glycemic control. One of these factors is hypertriglyceridemia. Aim of the Study: To assess the impact of severe hypertriglyceridemia (TG ≥ 1000 mg/dl) on HbA1c test results in type 2 diabetes mellitus. Patients and methods: A retrospective study on two groups of adult patients with type 2 DM; those with normal triglycerides levels (TG < 150 mg/dl) and those with severe hypertriglyceridemia (TG ≥ 1000 mg/dl) were implemented in Faiha Diabetes, Endocrine and Metabolism Centre (FDEMC) in Basrah–Iraq. A total of 267 patients with type 2 DM and severe hypertriglyceridemia and a total of 313 patients with type 2 DM and normal triglycerides levels were included. Both groups of patients were subdivided into sub-groups, each one with its specific range of FBS. Then the mean HbA1c of the patients with severe hypertriglyceridemia was measured in each FBS range and compared to the mean HbA1c of the patients with normal triglycerides levels in the same FBS range to determine the impact of severe hypertriglyceridemia on the readings of HbA1c in the diabetic patients (type 2). Results: The mean HbA1c in both groups were compared in each FBS range and revealed that despite nearly the same mean FBS, HbA1c was higher in patients with severe hypertriglyceridemia by 1.33% in the FBS range 130-149 mg/dl with a statistically significant p-value = 0.003. While it was lower in the FBS range 200-229 mg/dl, 230-259 mg/dl, 260-299 mg/dl, 300-349 mg/dl and 350-399 mg/dl by 1.02%, 0.85%, 1.77%, 2.29% and 2.23% respectively with a statistically significant p-value equals to 0.005, 0.034, < 0.001, < 0.001 and 0.039 respectively. There was no statistically significant difference between the mean HbA1c of both groups in the FBS range 72-129 mg/dl, 150-169 mg/dl and 170-199 mg/dl. Furthermore, the standard deviations of HbA1c in the severe hypertriglyceridemia group were generally higher than the standard deviations of HbA1c in the normal triglycerides levels group which indicates that the data were more spread out with higher HbA1c levels variation in the severe hypertriglyceridemia group. Conclusion: This study revealed that severe hypertriglyceridemia has a significant impact on HbA1c test results. The HbA1c values in diabetic patients (type 2) with severe hypertriglyceridemia are unpredictable. They may be equal to, higher or lower than the actual values. | ||
| Keywords | ||
| HbA1c test; Type 2 DM; Severe Hypertriglyceridemia | ||
|
Supplementary Files
|
||
|
Statistics Article View: 168 PDF Download: 134 |
||
