Determination of some hematological, biochemical parameters and vitamin D receptor gene polymorphism in Kurdish patients with COVID-19 in Erbil city | ||
| Kirkuk University Journal-Scientific Studies | ||
| Articles in Press, Accepted Manuscript, Available Online from 30 June 2023 PDF (311.52 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.32894/kujss.2023.137833.1093 | ||
| Authors | ||
| Ashna Talaat galaly* 1; Kalthum Asaaf Maulood2 | ||
| 1Department of Biology, College of Education, Salahaddin University, Erbil, Iraq. | ||
| 2Depatment of Biology, College of Education, University of Salahaddin, Erbil, Iraq. | ||
| Abstract | ||
| Coronavirus infection a new infectious illness brought on by the SARS-COV-2 virus has infected people worldwide as of 2019, a covid-19 disease is associated with hematological and biochemical parameters changes. The present study aimed to evaluate the possible relationship between patient parameters and disease severity. A total of 200 nasopharyngeal swabs and whole blood specimens were collected from individuals suspected of CoV-2 and healthy volunteers as control of both sexes, grouped into four groups:50 patients for each mild, moderate, and severe patients and 50 healthy volunteers. The current study demonstrated that female 82(55%) was more frequently affected than male 68(45%). Hematological parameters including white blood cell count (WBC), granulocyte count, and Red blood cell distribution width (RDW%) (increased significantly p < 0.05, while Lymphocyte count decreased significantly when compared with a control group. Significant differences in hemoglobin concentration, packed cell volume, red blood cell count, and indices of red blood cell count were shown when compared with a control group in both sexes. Regarding biochemical parameters including serum vitamin D, ferritin, D-dimer, procalcitonin (PCT), and liver function tests, serum vitamin D decreased significantly, while serum ferritin, D-dimer, procalcitonin and liver enzymes increased significantly in the covid-19 patients group compared to the control group. According to vitamin D receptor ,gene polymorphism in covid-19 patients genotype Bb was most likely associated and strongly related to getting infected with CoV-2 virus with all the three known stages of infection.Severity of CoV-2 was associated with leukocytosis, lymphopenia and biomarkers are the best predictors of severe CoV-2, with a strong relation of VDR gene polymorphism BsmI with the severity of CoV-2 patients | ||
| Keywords | ||
| SARS-CoV-2; Hematological parameter; Vitamin D; Procalcitonin; Vitamin D receptor BsmI | ||
| References | ||
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