Synthesis, Characterization of Substituted 1,3-Oxazepine, Thiazolidine-4-one and Azetidine-2-one Using Benzimidazole as a Synthon | ||
| Rafidain Journal of Science | ||
| Article 12, Volume 32, Issue 1, March 2023, Pages 110-120 PDF (831.58 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/rjs.2023.177293 | ||
| Author | ||
| Muhammed Kh. Muhammed | ||
| Iraqi Ministry of Environment/ Kirkuk Environment Directorate | ||
| Abstract | ||
| Starting from benzimidazole moiety, several heterocyclic compounds (1,3-Oxazepine, thiazolidin-4-one, azetidin-2-one) were synthesized, thus the Ethyl Benzimidazole acetate (1) was synthesized from the reaction of benzimidazole with ethylchloroacetate on treatment with hydrazine hydrate is giving the corresponding hydrazide (2). The reaction of this hydrazide with, 4-substituted acetophenone afforded hydrazones which on reaction with some reagents to produce synthesized compounds, (4a-c), (5a-c), (6a-c), (7a-c), (8a-c) and (9a-c). All the synthesized products were confirmed by physical and spectral methods. | ||
| Keywords | ||
| Heterocyclic; 1; 3-Oxazepine; Thiazolidine-4-one; Azetidine-2-one | ||
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