Husein, S., Al-Gharawi, A., Ghareeb, M. (2021). A Comparative Study of Single Dose versus Multiple Dose Prophylactic Ceftriaxone in Laparoscopic Cholecystectomy. Alustath, 21(3), 274-279. doi: 10.52573/ipmj.1970.175760
Sanaa Nasser Husein; Ali Abbas Al-Gharawi; Mowafaq Mohammad Ghareeb. "A Comparative Study of Single Dose versus Multiple Dose Prophylactic Ceftriaxone in Laparoscopic Cholecystectomy". Alustath, 21, 3, 2021, 274-279. doi: 10.52573/ipmj.1970.175760
Husein, S., Al-Gharawi, A., Ghareeb, M. (2021). 'A Comparative Study of Single Dose versus Multiple Dose Prophylactic Ceftriaxone in Laparoscopic Cholecystectomy', Alustath, 21(3), pp. 274-279. doi: 10.52573/ipmj.1970.175760
Husein, S., Al-Gharawi, A., Ghareeb, M. A Comparative Study of Single Dose versus Multiple Dose Prophylactic Ceftriaxone in Laparoscopic Cholecystectomy. Alustath, 2021; 21(3): 274-279. doi: 10.52573/ipmj.1970.175760

A Comparative Study of Single Dose versus Multiple Dose Prophylactic Ceftriaxone in Laparoscopic Cholecystectomy

Iraqi Postgraduate Medical Journal
Article 4, Volume 21, Issue 3, July 2022, Pages 274-279    PDF (178.46 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.1970.175760
Authors
Sanaa Nasser Husein1; Ali Abbas Al-Gharawi2; Mowafaq Mohammad Ghareeb3
1Clinical Pharmacy Specialist, AlKarama Teaching hospital Iraq.
2Baghdad Teaching Hospital, Baghdad, Iraq.
3Department of Pharmaceutics, College of pharmacy, University of Baghdad, Iraq.
Abstract
BACKGROUND:
Although laparoscopic cholecystectomy became the gold standard for the treatment of gallstone disease, there is some risk of surgical site infection that required prophylactic antibiotic. Prophylaxis for low risk patients is still controversial as well as whether single or multiple doses is needed.
AIM OF STUDY:
Compare between single vs. multiple dose of antibiotic prophylaxis in laparoscopic cholecystectomy in terms of post-operative infection and cost.
METHODS:
A prospective study conducted at Baghdad Teaching Hospital, from January 2017 to March 2018. 200 patients admitted for elective laparoscopic cholecystectomy randomly divided in two equal groups: single dose (SD) group was given ceftriaxone (2gm) intravenously at induction of anesthesia, and multiple doses (MD) group was given ceftriaxone (2gm) intravenously at induction of anesthesia followed by ceftriaxone (1gm) intravenously twice a day for two days postoperatively. Surgical site infection and treatment cost in two groups compared and analyzed.
 RESULTS:
 Postoperative infection rate was 1% in both groups; the difference was not significant (p=1).                 The cost was higher in MD group.
CONCLUSION:
Single dose prophylactic antibiotic administered at induction of anesthesia, is equally effective as multiple doses to prevent post-operative infection in low risk patients undergoing laparoscopic cholecystectomy and is cost effective.
 
Keywords
Laparoscopic cholecystectomy; antibiotic prophylaxis; ceftriaxone
References
  1. Deverick J Anderson, Daniel J Sexton. Antimicrobial prophylaxis for prevention of surgical site infection in adults. In Harris A, & Baron EL (Editors) , UpToDate, available from: https://www.uptodate.com/contents/antimicrobial-prophylaxis-for-prevention-of-surgical-site-infection-in-adults?search=postoperative%20wound%20infection&source=search_result&selectedTitle=5~150&usage_type=default&display_rank=5
  2. .Mortimore G. Gallstone disease: diagnosis and management.2
  3. Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut and liver. 2012;6:172.
  4. Tiderington E, Lee SP, Ko CW. Gallstones: new insights into an old story. F1000Research. 2016;5
  5. Singh P, Gupta SK, Kumar M. A comparative study of open cholecystectomy and laparoscopic cholecystectomy in patients with cholelithiasis. International Surgery Journal. 2017;5:253-56.
  6. Shukla A, Seth S, Ranjan A. A comparative study between laparoscopic and open cholecystectomy in cases of cholecystitis with cholelithiasis: one year experience in tertiary care center. International Surgery Journal. 2017;4:903-7.
  7. Mozafar M, Sobhiyeh MR, Moghadam LH. Infections after laparoscopic and open cholecystectomy: ceftriaxone versus placebo; a double blind randomized clinical trial. Archives of Clinical Infectious Diseases. 2010;5:3-8.
  8. Asgari S, Mohaghegh P, Ghorbani-Abdehgah A, Molavi B, Yaghoobi-Notash A, Mir A, Saeedi R, Nasiri S, Eslamian R, Shojaiefard A, Jafari M. Comparison of surgical site infections between laparoscopic and open cholecystectomy. Govaresh. 2018;22:266-70.
  9. Sasmal PK, Mishra TS, Rath S, Meher S, Mohapatra D. Port site infection in laparoscopic surgery: A review of its management. World Journal of Clinical Cases: WJCC. 2015;3:864.
10. 10.Matsui Y, Satoi S, Kaibori M, Toyokawa H, Yanagimoto H, Matsui K, Ishizaki M, Kwon AH. Antibiotic prophylaxis in laparoscopic cholecystectomy: a randomized controlled trial. PLoS One. 2014;9:e106702.

11. Uludag M, Yetkin G, Citgez B. The role of prophylactic antibiotics in elective laparoscopic cholecystectomy. JSLS: Journal of the Society of Laparoendoscopic Surgeons. 2009;13:337.

12. Sutariya PK, Thekdi PI. Single dose versus multiple dose prophylactic antibiotic in laparoscopic cholecystectomy: a comparative study. International Surgery Journal. 2016;3:633-36.

13. Darzi AA, Nikmanesh A, Bagherian F. The effect of prophylactic antibiotics on post laparoscopic cholecystectomy infectious complications: a double-blinded clinical trial. Electronic physician. 2016 ;8:2308.

14. Mirani AJ, Suchdev SD, Jatoi AH, Haseeb A, Idrees S, Younus SM. Use of antibiotic prophylaxis in low-risk laparoscopic cholecystectomy is unnecessary: a clinical trial. Pak J Med Health Sci. 2014;8:713-16.

15. Shah YD, Thekdi PI, Raut S, Patel KG. Single shot versus multiple shot antibiotic therapy in patients undergoing laparoscopic surgery: our experience. International Journal of Research in Medical Sciences. 2017;1:252-56.

16. lamb hm1, O.R.M.R.O.D.D, Scott lj, F.I.G.G.I.T.T.D.P. Ceftriaxone: an update of its use in the management of community-acquired and nosocomial infections. PubMed. 2002;62:1041-89.

17. Sharma R, Kajla RK, Jajra D, Mohanlal , Jakhar D. Role of Antibiotic Prophylaxis in Laparoscopic Cholecystectomy-A Randomized Prospective Study. Sch. J. App. Med. Sci., 2017;5:1652-55.

18. Kumar A, Patodia M, Pandove PK, Sharda VK, Pahwa S. Role of antibiotic prophylaxis in laparoscopic cholecystectomy: a randomized prospective study. Journal International Medical Sciences Academy. 2013;26:209-11.

19. Spaziani E, Picchio M, Di AF, Greco E, Cerioli A, Maragoni M, Facci G, Lucarelli P, Marino G, Stagnitti F, Narilli P. Antibiotic prophylaxis in elective laparoscopic cholecystectomy is useless. A prospective multicenter study. Annali italiani di chirurgia. 2015;86:228-33.

20. Abro AH, Pathan AH, Siddiqui FG, Syed F, Laghari AA. Single dose versus 24-hours antibiotic prophylaxis against surgical site infections. J Liaquat Univ Med Health Sci. 2014;13:27-31.

21. Matsui Y, Satoi S, Hirooka S, Kosaka H, Kawaura T, Kitawaki T. Reappraisal of previously reported meta-analyses on antibiotic prophylaxis for low-risk laparoscopic cholecystectomy: an overview of systematic reviews. BMJ open. 2018;8:e016666.

22. Lundström P, Sandblom G, Österberg J, Svennblad B, Persson G. Effectiveness of prophylactic antibiotics in a population-based cohort of patients undergoing planned cholecystectomy. Journal of gastrointestinal surgery. 2010;14:329-34.

23. Verma V, Sharma A. Role of Prophylactic Antibiotic in Low-risk Patients Undergoing Laparoscopic Cholecystectomy.

 

Statistics
Article View: 96
PDF Download: 56


Journal Management System. Powered by ejournalplus.com