Types of chromosomal abnormalities caused by chemotherapy cyclophosphamide in mice (Mus musculus L.) | ||
| Basrah Journal of Veterinary Research | ||
| Article 10, Volume 21, Issue 1, March 2022, Pages 107-123 PDF (1.47 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bjvetr.1970.173986 | ||
| Authors | ||
| Wasan Moayad Shaker; Zainab Abdul Rahman Mohammed Al tuma* | ||
| Abstract | ||
| The current study was designed to study the genetic effects of Mus musculus L. on male and female laboratory mice. The study included the following: Cyclophosphamide's effects on chromosomal changes in bone marrow cells and testes, as well as a study of Cyclophosphamide's effects on the mitotic index of bone marrow cells and germ cells (testes). Cyclophosphamide dosing resulted in a (0.006mg/kg body weight) for 30 days . Chromosomal changes appear in bone marrow cells (chromatid gap, chromatid break, centromere gap, ring chromosomes, centromere break, deletion) within a statistically significant difference (0.004). Cyclophosphamide also led to the occurrence of chromosomal changes in testicular cells (chromatid gap, centromere break, centromere gap, ring chromosomes, polyploidy) at a statistically significant difference (0.046). The results of the study also showed that the activity of cyclophosphamide caused a significant decrease in the mitotic index of bone marrow cells at the duration of the dose . at a statistically significant difference (0.016). For calculating the mitotic factor of the germ cell (testes), the results showed a decrease in the dose while there were no significant differences (p≥0.05). | ||
| Keywords | ||
| laboratory mice; Cyclophosphamide; mitotic index; Chromosomal changes | ||
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