Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery System

Atiyah, Nidhal A.; Atiya, Mohammed A.; Albayati, Talib M.

doi:10.30684/etj.v40i3.2174

	Curcumin Loaded onto Magnetic Mesoporous Material MCM-41 for Controlled and Released in Drug Delivery System
Engineering and Technology Journal
Article 5, Volume 40, Issue 3, March 2022, Pages 472-483 PDF (881.45 K)
Document Type: Research Paper
DOI: 10.30684/etj.v40i3.2174
Authors
Nidhal A. Atiyah^* ¹; Mohammed A. Atiya²; Talib M. Albayati¹
¹Chemical Engineering Dept, University of Technology-Iraq, Alsina’a street, 10066 Baghdad, Iraq.
²Chemical Engineering, Al-Khawarizmi College of Engineering, University of Baghdad.
Abstract
In this work, the mesoporous silica nanoparticles (MSNs) of type MCM-41 were manufactured and modified with Fe₃O₄ to load curcumin (CUR) CUR@Fe₃O₄/MCM-41 as an efficient carrier in drug delivery systems. X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FT-IR), and nitrogen adsorption-desorption isotherms were used to characterize the three samples: pure MCM-41, Fe₃O₄/MCM-41, & CUR@Fe₃O₄/MCM-41. Adsorption processes tests were carried out to determine the impact of various variables on the CUR load efficiency. These variables were the carrier dosage, pH, contact time, and initial CUR concentration. The maximal drug loading efficiencies (DL %) were 15.78 % and 22.98 %, respectively. According to the data, The Freundlich isotherm had a stronger correlation coefficient R²= 0.999 for MCM-41, while the Langmuir isotherm had a greater R² of 0.9666 for Fe₃O₄/MCM-41. A pseudo-second-order kinetic model fits well with R²=0.9827 for MCM-41 and 0.9994 for Fe₃O₄/MCM-41. Phosphate Buffer Solution (PBS) with a pH of 7.4 was utilized to study CUR release behavior. According to the research, the maximum release for MCM-41 and Fe₃O₄/MCM-41 might be 74.1 % and 25.19 % after 72 h, respectively. Various kinetic release models were used, including First-order, Korsmeyer-Peppas, Hixson and Crowell, Higuchi, and Weibull. After 72h, the drug release data were fit using a Weibull kinetic model with an R² of 0.944 and 0.764 for MCM-41 and Fe₃O₄/MCM-41, respectively.
Highlights
Functionalization of MCM-41 using Fe₃O₄. Encapsulation of curcumin onto MCM-41, Fe₃O₄/MCM-41 and their characterization before and after modified and loaded with curcumin. Comparison of release profile of curcumin loaded onto MCM-41 and Fe₃O₄/MCM-41. Investigation of the release mechanism and release kinetics
Keywords
Curcumin; Drug Delivery System; Fe3O4/MCM-41; Kinetic adsorption; Loading and release; Magnetic

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