Hypercholesterolemia as a risk factor for coronary heart disease | ||
| Journal of University of Anbar for Pure Science | ||
| Article 1, Volume 12, Issue 3, December 2018, Pages 1-8 PDF (482.83 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2022.171821 | ||
| Authors | ||
| Hadeel Al-daraji* 1; Akeel H. Ali Al-Assie2; Rada H. Hussien3 | ||
| 1Anbar University , College of Sciences, Dept of Biology | ||
| 2Tikrit University , College of Sciences , Dept of Biology | ||
| 3Sulaymaniyah University , College of Sciences , Dept of | ||
| Abstract | ||
| Familial Hypercholesterolemia (FH) is a genetic disorder, an expression of a defect in the gene that is responsible for the production of LDL-C receptor. The current study was designed to determine the FH patients in the city of Sulaymaniyah for both sexes. The study included 213 samples, the number of males was 99 and the number of females was 114, both sexes ranged from (30-79) years.The results of cholesterol, triglyceride, high density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) in patients with hypercholesterolemia showed highly significant (P ˂ 0.01) for cholesterol and the concentration level in patients with hypercholesterolemia compared to the level of concentration of healthy.As concerns the effect of hypercholesterolemia on coronary heart disease, the results showed a significant increase (P ˂ 0.01) in cholesterol, triglycerides and LDL-C with a significant decrease in HDL-C concentration in people with heart disease compared with healthy people. triglyceride in patients with compared healthy people. (HDL-C and LDL-C) showed a significant decrease (P ˂ 0.01) in the concentration of HDL-C in patients with hypercholesterolemia compared to their level of concentration in healthy individuals, in relation to low-density lipoprotein (LDL-C) -C is the other (P ˂ 0.01) in. | ||
| Keywords | ||
| Lipid profile; Coronary Heart Disease | ||
| References | ||
|
1-Al-Shamary , A. and Ibraheem , M. N.(2011). Hypercholesterolemia and Acute Myocardial Infarction. Iraqi J. Comm. Med., Apr 9:125-127.
2-Abifadel, M.;Varret, M.; Rabes, JP.; et al. (2003).Mutations in PCSK9 cause autosomal dominant hypercholesterolemia . Nat Genet. 34(2):154-156.
3-Fouchier , S.W.; Kastelein ,J.J.P.; Defesche,J.C.(2005).Update of the molecular basis of familial hypercholesterolemia in the Netherlands . Human Mutation. vol. 26 , no. 6 , p: 550-556.
4-Leighi, S.E.A.; Foster, H.; Whittall, R.A.; Hubbart, C.S.; Humphries, S . E . (2008) . Update and analysis of the university College London low density lipoprotein receptor familial hypercholesterolemia database . Annals of Humman Genetics.Vol.72, No 4, pp. 485-498 .
5-Martínez-Martínez, I., Montoro-García, S., Lozada-Ramírez, J. D., Sánchez-Ferrer, Á., & García-Carmona, F. (2007). A colorimetric assay for the determination of acetyl xylan esterase or cephalosporin C acetyl esterase activities using 7-amino cephalosporanic acid, cephalosporin C, or acetylated xylan as substrate. Analytical Biochemistry, 369(2), 210–217.
6-Ahmadi, S.-A., Boroumand, M.-A., Gohari-Moghaddam, K., Tajik, P., & Dibaj, S.-M. (2008). The impact of low serum triglyceride on LDL - cholesterol estimation. Archives of Iranian Medicine, 11(3), 318–321.
7-Dong, J., Guo, H., Yang, R., Li, H., Wang, S., Zhang, J., & Chen, W. (2011). Serum LDL- and HDL-cholesterol determined by ultracentrifugation and HPLC. Journal of Lipid Research, 52(2), 383–388.
8-Salazar, LA.; Hirata, MH.; Forti, N.; Diament, J.; Giannini, SD; Issa, J. ; Hirata , RDC . (2000) . II intron 15 polymorphism at the LDL Receptor gene is associated with differences in serum Lipid concentrations in individuals with low and high risk for Coronary Artery disease from Brazil.293: 75-88.
9-Farrokhi, E.; Shayestesh, F.; Asadi, S.; Roghani, F.;Ghatreh, K.; Hashemzadeh , M.( 2008 ). Molecular characterization of Iranin Patients with possible familial hypercholesterolemia.Ind.J. Clin Biochem. 26 (3) : 244-248.
10-Vander, S.; Widmaier, L.; Eric, K.; and Hershel, R.(2004). Human physiology the mechanism of body function , 9th ed published by Mc Graw -Hill companies NewYork,p .442.
11-Dineshkumar, B.; Analava, M. and Manjunatha, M. (2010). studies on the anti – diabetic and hypolipidemic potentials in type 2 Diabetic patients " . International Jonrnal of Advances in pharmaceutical sciences, 1: 75 -85 .
12-Grundy, S.M. (2009). Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome,The American journal of cardiology, 81: 18-25 .
13-Bronk, R.(1999). Human metabolism functional diversity and. Integration .4th ed.Addison Wesley Longman Limited., pp.228.
14-Morrison , A. ; Hokanson, J. E.; Venge , P.(2009). The independent relationship between triglycerides and coronary heart Disease . Vasc. Health Risk Manag . 5 : 89 – 95 .
15-Labreuche, J.; Touboul , P. J. and Amarenco , P. (2009) . Plasma triglyceridelevels and risk of stroke and carotid atherosclerosis : a systematic review of the epidemiological studies . Atherosclerosis .203 : 331 – 345 .
16-Hossein, M.D. (2014) . A survey of the Relationship between Serum Cholesterol and Triglyeride to Glaucoma : A Case control study . Medically . Vol. (10) . pp : 334-400 .
17-Coyle, E.F. (2000). Physical activity as metabolic stressors". Am. Clin.Nutr. Suppl. 72: 512-520 .
18-Gygi, F. R. (2014). Museum objects experiencing the properties of things, Dudley, Sandra H. (ed.). Material Religion, 10(1),115–116.
19-Rifai, N.; Bachorik, P. and Albers, J. (2004). Lipids, lipoproteins and Apo proteins . In : Tietz Fundamentals of clinical chemistry. Burtis CA and Ashwood ER ( eds ) . 5th ed . W.B. Saunders Company, Philadelphia, p : 462-493 .
20-Marta, M.M ; Duarte, F. ; Joao, B. ; Rafael, N. ; Thiago, D. ; Ivana, B. M . ; Maria , R .C . ( 2009 ) . Association between ischemia modified albumin , Lipids and inflammation biomarkers in Patients with hypercholesterolemia.Clinibiochem , p : 666-671.
21-Lloyd-Jones, D. M. (2014). Niacin and HDL Cholesterol - Time to Face Facts. New England Journal of Medicine, 371(3), 271–273 .
22-Guytun, C. and Hall, T. (2010). Text book of medical physiology".10 th ed . W. B . Sanders company . New York . p :774-789 .
23-Fruchart, J.C. and Packard, C.J. (2007). Is cholesterol the major lipoprotein risk factor in coronary heart disease ? " A Franco Scottish overview . Curr Med . Res . Opin . 13 : 603 – 616.
24-Thibodeau , G . A. and Patton , K . T .( 2003) .Anatomy and Physiology 5th ed . Mosby , Inc. , p : 925 – 927 .
25-Brewer, H. B. (2004). Focus on high density lipoproteins in reducing Cardiovascular risk. Am. Heart. J; 148: 14-18 .
26-Murray, R. K.; Granner, D. K.; Mayes, P.A.; (2010) Harpers. Biochemistry : lipid transport and strorage . 25th ed by mays A Appleton and lange, Lebanon. By typopress ,27: 268-282.
27-Fatimah, M. Y. ; Mohd, H.S. ; Muhammad, F. H. ; Siti, R.H. (2016 ) . Lipid profile of the Coronary Heart Disease (CHD) patients Admitted in a hospital in Malaysia. Journal of Applied pharmaceutical Science .Vol.6 (50) . p : 137-142 .
28-Nayab, B. ; Saeed, A.N. (2012) . Literature Review : Cardiovascular Disorders and Lipidprofile . Atherosclerosis , Vol.(38) , p : 205-230 .
29-Carmena, R.; Duriez, P.; Fruchart, JC.(2004).Atherogenic lipoprotein. Particles in Atherosclerosis. Circulation , Vol. (109) , p : 7-1112 .
30-Mills, P. ; Chong , G. ; Ghement, I. ; Singh, S. ; Guyatt, G. (2011). Efficacy and safety of statin treatment for cardiovascular disease a network meta- analysis of 170 . 255 patients from randomized trials QJM : Journal of the Association of physicions . 104 : ( 2 ) : 109-24 . | ||
|
Statistics Article View: 124 PDF Download: 110 |
||