Protective Effect of Zinc Sulfate on Hypo-and Hyperthyroidism Induced in Adult Male Rabbits | ||
| Basrah Journal of Veterinary Research | ||
| Article 1, Volume 20, Issue 2, December 2021, Pages 1-15 PDF (1.03 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bvetr.1970.170493 | ||
| Authors | ||
| Nooralhuda Falih; Jassim Alkalby | ||
| Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, Iraq | ||
| Abstract | ||
| The present study was conducted to investigate the effect of co-administration of zinc sulfate with Carbimazole (CBZ) and, Levothyroxine (L-T4) on thyroid gland function in adult male rabbits. Fifty adult male rabbits, were divided randomly into five equal groups (6 rabbits/group) as follows: The first group (control group): Rabbits were given oral doses of distilled water daily by gavage; second group (Hypothyroidism): Rabbits were given oral doses of carbimazole (5 mg/kg. bw) daily by gavage; the third group; Rabbits were given oral doses of carbimazole (5 mg/kg. bw) + zinc sulfate (20 mg/kg.bw); fourth group (Hyperthyroidism): Rabbits were given oral doses of L-T4 (100µg/kg.bw) daily by gavage; Fifth group: Rabbits were given oral doses of L-T4(100µg/kg.bw) + Zinc sulfate (20mg/kg.bw) daily by gavage. The treatment continued for 30 days. The results revealed the following: A significant elevation in serum TSH level and a significant reduction in serum T4, T3 and, FT3 levels in CBZ treated rabbits group compared with the control group, while a significant reduction in serum TSH level and a significant elevation in serum levels of T4, FT4 and FT3 in animals group treated with the L-T4 compared with the control group Histopathological changes of hypothyroidism were observed in CBZ treated group characterized by small thyroid follicles, increase the height of thyrocytes hyperplasia, and vacuolation of colloid. L-T4 and L-T4-Zinc treated groups showed large follicles distended with homogenous acidophilic colloid. No significant changes in thyroid architecture were observed in CBZ-Zinc treated group compared with the control group. | ||
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