Outcome of treatment among chronic lymphocytic leukemia and its correlation to Rai staging system in Kurdistan region of Iraq

Ahmad, Zhala; Hasan, Kawa; Al-Rawi, Hisham; K. Yassin, Ahmed; Rashid, Bryar; Mahmood, Tavan; Mohamed, Zeki; Mohammed, Nawsherwan; Jalal, Sana; Abdulla, Basil; Abdullah, Dana; Mustafa, Shokhan; Mohammed, Shlan; Abdulrahman, Lara; Karam, Mrawa; Obaid, Ghanem; Yousif, Rozhat; Polus, Ranan; Shamoon, Rawand

doi:10.33899/mmed.2021.130017.1090

	Outcome of treatment among chronic lymphocytic leukemia and its correlation to Rai staging system in Kurdistan region of Iraq
Annals of the College of Medicine, Mosul
Article 1, Volume 43, Issue 2, December 2021, Pages 100-108 PDF (393.05 K)
Document Type: Research Paper
DOI: 10.33899/mmed.2021.130017.1090
Authors
Zhala Ahmad^* ¹; Kawa Hasan²; Hisham Al-Rawi³; Ahmed K. Yassin⁴; Bryar Rashid⁵; Tavan Mahmood⁵; Zeki Mohamed⁶; Nawsherwan Mohammed⁷; Sana Jalal⁸; Basil Abdulla⁹; Dana Abdullah¹⁰; Shokhan Mustafa¹¹; Shlan Mohammed¹¹; Lara Abdulrahman¹¹; Mrawa Karam¹¹; Ghanem Obaid¹²; Rozhat Yousif¹³; Ranan Polus¹⁴; Rawand Shamoon¹⁵
¹department of Adult clinical Hematology , Hiwa cancer center, Sulaimaniah
²Department of Medicine, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
³Department of Pathology, College of Medicine, University of Sulaymaniyah, Sulaymaniyah, Kurdistan Region, Iraq.
⁴Department of medicine, college of medicine, Hawler medical university, Kurdistan region, Iraq
⁵M.B.Ch.B., trainee at Kurdistan Board-Hematology-Hiwa Oncology center
⁶Department of Medicine, College of Medicine, University of Duhok, Duhok, Kurdistan Region, Iraq
⁷Department of Pathology, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region, Iraq
⁸MBChB, FIBMS-path, FRCPath, Department of Pathology, College of Medicine, University of Sulaymaniyah, Sulaymaniyah, Kurdistan Region, Iraq
⁹MBChB, FIMS-hemato-oncology, Department of Hematology, Hiwa Cancer hospital, Sulaymaniyah, Kurdistan Region, Iraq
¹⁰Department of Pathology, College of Medicine, University of Sulaymaniyah, Sulaymaniyah, Kurdistan Region, Iraq
¹¹M.B.Ch.B., trainee at Kurdistan Board-Hematology-Nanakali Oncology center
¹²consultant hematologist and internist , Nanakali Hospital
¹³M.B.Ch.B., trainee at Kurdistan Board-Hematology-Duhok Hematology center
¹⁴Hematopathology ,College of Medicine, Hawler Medical University, Erbil, Kurdistan Region, Iraq
¹⁵hematopathology, Department of Pathology, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region, Iraq,
Abstract
*Background:* Chronic lymphocytic leukemia is common adulthood leukemia with low incidence in Kurdistan region of Iraq. Staging of chronic lymphocytic leukemia is essential in treatment planning and the pattern of response is variable. *Aim of study:* To evaluate the Rai staging distribution of patients with chronic lymphocytic leukemia in Kurdistan region/Iraq and its correlation with the treatment outcome. *Patients & Methods:* A retrospective cross sectional review study conducted in three Hemato/oncology centers in Kurdistan for duration of eleven years through the period from 1^st of January, 2010 to 31^st of December, 2020 on convenient sample of 170chronic lymphocytic leukemia patients. Diagnosis of chronic lymphocytic leukemia was done according to the International Workshop on Chronic Lymphocytic Leukemia. The Rai staging was done by the clinical hematologist in Hemato/oncology center according to clinical evaluation and laboratory investigations. The pattern of the treatment response was determined according to the International Workshop on Chronic Lymphocytic Leukemia (iwCLL) *Results:* The Rai staging of our patients was 0 in 15.3% of them, stage I in 12.4%, stage II 30%, stage III 13.5% and stage IV 28.8%. The treatment response of studied sample was complete response (43.5%), partial response (17.6%), stable (14.1%), no response (21.8%) and progressive (2.9%).A highly significant association was observed between no response to treatment and advanced Rai staging and also a highly significant association was observed between death outcome of patients and advanced Rai staging. *Conclusions:* The treatment response of patients with chronic lymphocytic leukemia is directly related to Rai staging as patients with advanced Rai staging had lower treatment response rate.
Keywords
Chronic Lymphocytic Leukemia,,; ,،,؛Rai staging,,; ,،,؛Treatment response

Statistics Article View: 472 PDF Download: 302