Effect of Thymol Incorporation on Antibacterial Activity of the Locally Prepared Zinc Oxide-Guaiacol Root Canal Sealer: An in Vitro Study | ||
| Al-Rafidain Dental Journal | ||
| Article 12, Volume 21, Issue 2, September 2021, Pages 270-280 PDF (547.7 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/rden.2021.128787.1061 | ||
| Authors | ||
| Fatin S Mohammed* 1; Sawsan Al-jubori2 | ||
| 1iraq-mosul | ||
| 2Mosul University | ||
| Abstract | ||
| Aims: This study aimes to prepare a new formula by thymol crystals incorporation into locally prepared zinc oxide-guaiacol root canal sealer and evaluating the antibacterial activity and comparing the results with zinc oxide eugenol-based root canal sealer. Materials and Methods: The addition of thymol crystals at three different concentrations (2%, 5%, and 10%) to improve the antibacterial activity of zinc oxide-guaiacol endodontic sealer was done: 40 Petri plates of Enterococcus agar media were used, each plate with five wells. Petri plates divided into four groups incubation intervals (1, 2, 3, and 7 days) for each type, using agar diffusion test (ADT) with 0.5 McFarland turbidity standards and statistically analyzed using descriptive statistics, a one-way ANOVA test, and Duncanʼs Multiple Range Test. Results: The thymol incorporated zinc oxide-guaiacol sealer groups at studied concentrations (2%, 5%, and 10% ) produced bacterial growth inhibition zones persisted at all incubation time intervals at (1, 2, 3, and 7 days) and high significantly at p≤0.01 than that of zinc oxide eugenol based sealer. There is a significant reduction at p≤0.01 in antibacterial efficacy in all incorporation groups at 7 days incubation period, 5% thymol incorporation group with significant largest bacterial growth inhibition zones for all incubation periods. Conclusions: This study concluded that the prepared zinc oxide - guaiacol sealer formulas with three studied thymol crystals concentrations having better antibacterial efficacy than that of zinc oxide eugenol root canal sealer, 5% thymol incorporation formula is the best in antibacterial activity than others. | ||
| Keywords | ||
| Endodontic sealer,,; ,،,؛Zinc oxide eugenol,,; ,،,؛Agar diffusion test,,; ,،,؛Enterococcus faecalis | ||
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