Synthesis of Some New Derivatives of Pyrrolidine-2-one and Studying Their Antibacterial Potentials | ||
| Engineering and Technology Journal | ||
| Article 5, Volume 38, 3B, December 2020, Pages 128-141 PDF (1.43 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.30684/etj.v38i3B.706 | ||
| Authors | ||
| Nadia A. Betti* 1; Redha Ib. Hussain2; Sahar Ab. Kadhem2 | ||
| 1Materials Engineering Department, University of Technology, Baghdad, Iraq | ||
| 2Department of Chemistry, Mustansiriyah University, Baghdad, Iraq. | ||
| Abstract | ||
| New derivatives of pyrrolidine-2-one have been synthesized through lactamization of γ –butyrolactone (GBL) by hydrazine hydrate (80%), ethylene diamine and ethanol amine to afford compounds (1-aminopyrrolidin-2-one), (1-(2-aminoethyl)pyrrolidine-2-one) and (1-(2-hydroxyethyl)pyrrolidine-2-one), respectively. Compound (1-aminopyrrolidin-2-one) underwent several reactions to synthesize the rest of these derivatives. All synthesized compounds were approved by their FT-IR, 1H-NMR and some by Mass spectra. The biological activities of these derivatives were evaluated against Escherichia coli and Staphylococcus aureus. Many of these derivatives showed moderate biological activity against one or both kind of bacteria in comparison to amoxicillin and some showed no biological activity at all. | ||
| Keywords | ||
| Pyrrolidine-2-one; Lactamization; biological activity | ||
| References | ||
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