Clinical and Histological Effects of N-acetyl Cysteine Intraperitoneal Injection on Primary Wound Healing in Rabbits. | ||
| Al-Rafidain Dental Journal | ||
| Article 2, Volume 21, Issue 2, September 2021, Pages 165-176 PDF (818.22 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/rdenj.2021.129487.1087 | ||
| Author | ||
| Zaid muhammad* | ||
| Department of Oral and Maxillofacial Surgery – Mosul Dental College - University of Mosul-Iraq | ||
| Abstract | ||
| Aims: This study aims to investigate the effect of ten days of intraperitoneal injection of N-acetyl cysteine (NAC) on full thickness wound healing of the skin, using a rabbit model. Materials and Methods: Thirty - male rabbits were used to conduct this study. A full – thickness linear incision, (10 mm) was induced on the back of each rabbit and divided into two groups. Group 1: no treatment (control group) and group 2 (NAC-treated group) was injected intraperitoneally ten days before wound induction. Animals were randomly divided into three groups according to sacrificing date (1, 3 and 7) days. The site of intervention was assessed clinically and histopathologically on the 1st, 3rd, and 7th day of the experimental procedure. Results: The clinical observation of tissue type revealed that there were significant differences in type of tissue at 1 and 3 days at p-value ≤ 0.05, and the wound healing was converted to granulation tissue without slough and necrotic tissue formation. There was no significant difference at 7 days compared to the control group. The histopathological finding showed that there were significant differences in angiogenesis and granulation tissue formation between the two groups at 1 and 3 days at p-value ≤ 0.05, while there was no significant difference at 7 days. There was a significant difference of reepithelization at 3 and 7 days at p-value ≤ 0.05., Conclusions: Ten days of intraperitoneally N-acetyl cysteine injection before surgical procedures will significantly enhance the process of primary wound healing of rabbit skin.on secondary wounds. | ||
| Keywords | ||
| N-acetyl cystine,,; ,،,؛intraperitoneal,,; ,،,؛wound healing,,; ,،,؛epithelialization | ||
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