Abdulamir, A., Hafidh, R. (2020). Viral load, T-Cells Count, and T-cells SARS-CoV-2 Cross-Reactivity Constitute a Triad Governing the Varied Prognosis of COVID-19. Alustath, 20(1), -. doi: 10.52573/ipmj.2020.167818
Ahmed Sahib Abdulamir; Rand Riadh Hafidh. "Viral load, T-Cells Count, and T-cells SARS-CoV-2 Cross-Reactivity Constitute a Triad Governing the Varied Prognosis of COVID-19". Alustath, 20, 1, 2020, -. doi: 10.52573/ipmj.2020.167818
Abdulamir, A., Hafidh, R. (2020). 'Viral load, T-Cells Count, and T-cells SARS-CoV-2 Cross-Reactivity Constitute a Triad Governing the Varied Prognosis of COVID-19', Alustath, 20(1), pp. -. doi: 10.52573/ipmj.2020.167818
Abdulamir, A., Hafidh, R. Viral load, T-Cells Count, and T-cells SARS-CoV-2 Cross-Reactivity Constitute a Triad Governing the Varied Prognosis of COVID-19. Alustath, 2020; 20(1): -. doi: 10.52573/ipmj.2020.167818

Viral load, T-Cells Count, and T-cells SARS-CoV-2 Cross-Reactivity Constitute a Triad Governing the Varied Prognosis of COVID-19

Iraqi Postgraduate Medical Journal
Article 1, Volume 20, Issue 1, January 2021    PDF (178.81 K)
Document Type: Review Paper
DOI: 10.52573/ipmj.2020.167818
Authors
Ahmed Sahib Abdulamir1; Rand Riadh Hafidh2
1Medical Microbiology Department, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
2Medical Microbiology Department, College of Medicine, University of Baghdad, Baghdad, Iraq.
Abstract
The novel coronavirus disease, COVID-19, impose a challenge on scientists and physicians in terms of understanding the phases of viral pathogenesis and host immunopathogenesis that lead to the fatal complications of the disease. Three pillars have been thought to play essential role in determining the prognosis of COVID-19, namely the viral load of SARS-CoV-2, the count and functionality of T lymphocytes and the crossreactivity of T lymphocytes with common cold coronaviruses. Collectively, these three factors might constitute a triad governs the time-based and phase-based progression of COVID-19
patients. This review discusses the role of this triad in COVID-19 and presents the so far accumulated knowledge and research that justify the central role of this triad of factors in disease prognosis. Understanding the factors control disease progression is most important in helping physicians to treat the multi-phased host-microbe disease.
Keywords
Coronavirus; Covid_19; SARSCoV-2; T cells; Viral load; T cells cross reactivity
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