Synthesis and Characterization of Some Schiff Bases Derived from Carboxymethyl Chitosan and Evaluating The Biological Activity of Some of these Derivatives | ||
| Kirkuk Journal of Science | ||
| Article 4, Volume 15, Issue 4, December 2020, Pages 56-86 PDF (2.63 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.32894/kujss.2021.167518 | ||
| Authors | ||
| Ahmed A. H. Al-kadhimi1; Moneer Khadhim Muhsin2; Marwan Ahmed Jassim Ahmed Jassim Shahir Al-Salami* 1 | ||
| 1Department of Chemistry, College of Science, Kirkuk University, Kirkuk, Iraq. | ||
| 2Ministry of Sciences and Technology, Baghdad, Iraq. | ||
| Abstract | ||
| This study included the synthesis of O-carboxymethyl chitosan which contains amine group attached directly to its glucose unit from the well-known natural polymer (chitosan), which in turn was reacted with some aromatic aldehydes containing o- and p- substituents to prepare a series of Schiff bases compounds. The used aldehydes were; p-boromobenzaldehyde, o-hydroxybenzaldehyde, o-bromobenzaldehyde, p-chlorobenzaldehyde, and p-nitrobenzaldehyde. The synthesized compounds were characterized using spectroscopic techniques including FT-IR and 1H-NMR. The thermal stability of some of the prepared compounds was checked using differential thermaogravimetric analysis DTA. Finally, the biological activity of two Schiff bases was measured against two types of bacteria (Escherichia coli) and (Staphylococcus aureus) in terms of inhibition rate. | ||
| Keywords | ||
| O-carboxymethyl chitosan; Carboxymethyl chitosan Schiff bases; Chitosan | ||
| References | ||
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