Incidence and predictors of acute kidney injury among hospitalized patients with COVID-19 infection | ||
| The Medical Journal of Basrah University | ||
| Article 5, Volume 38, Issue 2, December 2020, Pages 37-45 PDF (453.22 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2020.128481.1038 | ||
| Authors | ||
| Hayder Aledan* 1; Shawqi Azeez2; Abdali Shannan3; Ammar Husaini3; Muqtader Abdulhussein4 | ||
| 1Medicine, College of Medicine, University of Basrah | ||
| 2Anasthesia and Intensive Care Unit | ||
| 3Internist | ||
| 4Resident | ||
| Abstract | ||
| Abstract Background and objectives: Acute kidney injury (AKI) may occur in the setting of COVID-19 infection and associated with worse outcome. We aimed to estimate the incidence of AKI among hospitalized patients with COVID-19 infection. Methods: We conducted an observational cohort study on 339 hospitalized patients with COVID-19 infection at Basra teaching hospital for two months. We studied the rate of AKI, requirement for renal replacement therapy (RRT) and in-hospital mortality. Results: Among 339 hospitalized patients, AKI was reported in 54 (16%). The peak stages of AKI were stage 1 in 42.6%, stage 2 in 22.2% and stage 3 in 35.2%. AKI was primarily seen in patients with shock on vasopressors in 64.8% and in patients on mechanical ventilation in 25.9%. Increased age, obesity, hypertension, vasopressors and mechanical ventilation were independent risk factors for development of AKI. Among the 54 patients with AKI, 20 patients (37%) required renal replacement therapy (RRT). Sixteen out of 20 patients (80%) of those who required RRT died and only 5 out of 34 patients (15%) of those not required RRT died with a totally mortality in AKI patients of 21 patients (39%). Conclusions: AKI occurs in patients with COVID-19 disease especially in ICU in association with vasopressors use and mechanical ventilation and is associated with poor prognosis. | ||
| Keywords | ||
| Covid_19; acute kidney injury; intensive care unit; Mechanical ventilation; vasopressors | ||
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