Incidence and predictors of acute kidney injury among hospitalized patients with COVID-19 infection
|The Medical Journal of Basrah University|
|Article 5, Volume 38, Issue 2, December 2020, Pages 37-45 PDF (453.22 K)|
|Document Type: Research Paper|
|Hayder Aledan* 1; Shawqi Azeez2; Abdali Shannan3; Ammar Husaini3; Muqtader Abdulhussein4|
|1Medicine, College of Medicine, University of Basrah|
|2Anasthesia and Intensive Care Unit|
Background and objectives: Acute kidney injury (AKI) may occur in the setting of COVID-19 infection and associated with worse outcome. We aimed to estimate the incidence of AKI among hospitalized patients with COVID-19 infection.
Methods: We conducted an observational cohort study on 339 hospitalized patients with COVID-19 infection at Basra teaching hospital for two months. We studied the rate of AKI, requirement for renal replacement therapy (RRT) and in-hospital mortality.
Results: Among 339 hospitalized patients, AKI was reported in 54 (16%). The peak stages of AKI were stage 1 in 42.6%, stage 2 in 22.2% and stage 3 in 35.2%. AKI was primarily seen in patients with shock on vasopressors in 64.8% and in patients on mechanical ventilation in 25.9%. Increased age, obesity, hypertension, vasopressors and mechanical ventilation were independent risk factors for development of AKI. Among the 54 patients with AKI, 20 patients (37%) required renal replacement therapy (RRT). Sixteen out of 20 patients (80%) of those who required RRT died and only 5 out of 34 patients (15%) of those not required RRT died with a totally mortality in AKI patients of 21 patients (39%).
Conclusions: AKI occurs in patients with COVID-19 disease especially in ICU in association with vasopressors use and mechanical ventilation and is associated with poor prognosis.
|Covid_19; acute kidney injury; intensive care unit; Mechanical ventilation; vasopressors|
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