Preparation, Characterization and Evaluation Biological Activity of Cobalt (II) with Mixed Ligands complexes | ||
| Journal of Education and Science | ||
| Article 29, Volume 30, Issue 2, June 2021, Pages 1-18 PDF (1.22 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/edusj.2020.128321.1110 | ||
| Authors | ||
| Ahlam Mohammed Yaseen Al-Bayati* 1; Zuhoor Fathi Dawood2 | ||
| 1Department of Chemistry / College of Science / University of Mosul | ||
| 2Department of Chemistry / College of Education for Pure Sciences / University of Mosul | ||
| Abstract | ||
| New cobalt (II) complexes with mixed ligands including [(2- oxime-4-hydrazone) pentane (L1H) and 2-chlorobenzaldehyde thiosemicarbazone(T1H) ,or 3,4-dimethoxy acetophenone thiosemicarbazone (T2H); glycine (GH) or metformin (mf)] have been prepared in both pH (6.5-7) and (9.5-10) using classical and microwave techniques. The resulting complexes have been characterized using physio- chemical and spectral techniques. The study suggested that the complexes have the generalformulate [Co(L1H)(TH)(BH)](CH3COO)2and[Co(L1)(TH)(G)]or[Co(L1)(T)(mf)] at pH (6.5-7) and (9.5- 10), respectively {where TH= T1H or T2H; T= deprotonated T1H or T2H; L1H=L1=deprotenated; BH= GH or mf; G= deprotonated GH]. Hexacoordinated mononuclear complexes having distorted octahedral geometries have been investigated. The biologicall activity of the ligands and complexes have been evaluated by agar plate diffusion technique against Echerichia coli, Klipsila pnnemoia, Staphylococcus aureus and Pseudomonas aeruginosa. Some compounds have been found to have antibacterial activity. | ||
| Keywords | ||
| Mixed ligands; Cobalt (II) complexes; thiosemicarbazone; metformin glycine | ||
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