The Role of Homocysteine and CA125 in the Differentiation between Ectopic Pregnancy and Spontaneous Abortion in First Trimester | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 11, Volume 19, Issue 2, June 2020, Pages 156-164 PDF (0 K) | ||
| Authors | ||
| Sahar Abdul Baqi AL- Dulaimi; Ekhlass Hussam Al-Rawi; Shaimaa Adnan Ahmed; Maha Mohammed Al- Bayati; Sahar Abdul Baqi AL- Dulaimi; Ekhlass Hussam Al-Rawi; Shaimaa Adnan Ahmed; Maha Mohammed Al- Bayati | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: Ectopic pregnancy and spontaneous abortion are the two common complications seen in early pregnancy. While spontaneous abortion is the most common complication of pregnancy, ectopic pregnancy is the most life threatening emergency in early pregnancy. OBJECTIVE: To investigate the diagnostic value of serum homocysteine and CA-125 levels for early diagnosis and differentiation for early pregnancy complications. PATIENTS AND METHODS: The study included 90 pregnant women, aged from 21 to 40 years old presented with a gestational age ranging between 5-13 weeks. The patients were divided into three groups, group A included 30 cases of ectopic pregnancies, group B Included 30 cases who presented with spontaneous abortions and group C included 30 cases who presented as normal uncomplicated pregnancies and were followed up till their normal term deliveries and was considered as the control group. All women in the studied groups underwent CA125 and serum homocysteine measurements by radioimmune assay and Enzyme-linked immunosorbent assay (ELISA) respectively. RESULTS: Regarding group A, the majority of cases had low levels of serum homocysteine on admission (60%) and only one case changed from low to high level after one week from surgical termination of pregnancy. The CA125 readings were subdivided into two subdivisions: the first subdivision was the ruptured ectopic pregnancy cases on admission and diagnosis and they were 20 out of the 30 cases of ectopic pregnancy, half of these cases (50%) had high CA125 levels on admission and 3 patients had returned to normal after one week from surgical termination of pregnancy, in the second subdivision (unruptured ectopic pregnancies which were10 cases), the vast majority of patients (90%) had normal CA125 levels on admission and all of them had returned to normal after one week from the surgical termination of pregnancy. Regarding group B, (56.7%) of patients had high levels of serum homocysteine on admission and none of them had returned to normal value after one week from spontaneous or interventional completeness of the abortion, while the results of CA125 showed that (63.3%) of patients had high levels of this tumor marker on admission and 6 cases had returned to normal levels after one week from spontaneous or interventional completeness of the abortion. In group C, the majority of the cases were within normal ranges of both CA125 and serum homocysteine both at admission and one week follow up. (90% and 93.3% regarding CA125) and (76.6% and 70% regarding serum homocysteine). CONCLUSION: The measurement of serum homocysteine and CA125 was found to be an effective method for early diagnosis and differentiation between spontaneous abortion and ectopic pregnancy. | ||
| Keywords | ||
| pregnancy; spontaneous abortion; Ectopic pregnancy; homocysteine; Pregnancy | ||
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