Applying P40 and TTF-1 in the Subtyping of Poorly Differentiated Non-Small Cell Lung Carcinoma in Bronchoscopic Biopsy | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 10, Volume 19, Issue 3, September 2020, Pages 239-245 PDF (0 K) | ||
| Abstract | ||
| BACKGROUND: Lung cancer is the leading cause of cancer-related deaths worldwide, regardless of gender. It is categorized into two main groups: small cell lung carcinoma (SCLC, 15% of all lung cancers) and non-SCLC (NSCLC, 85% of all lung cancer). Increasing knowledge of the molecular pathology of lung cancers has led to their classification into specific subtypes according to appropriate treatments and molecular-targeted therapies. OBJECTIVE: Evaluation of the expression of P40 and TTF-1 in randomly selected samples from Iraqi patients who have NSCLC and correlate their expression with the clinicopathological variables. PATIENTS AND METHODS: This is a retrospective study of 40 patients who were diagnosed to have NSCLC. Formalin fixed, paraffin embedded tissue blocks.P40 and TTF-1 immunoreactivity and pattern of staining were evaluated in immunohistochemical stained slides and correlated the results with clinicopathological parameters. RESULTS: 55% of the tumors were squamous cell carcinoma while 45% were adenocarcinoma. The sensitivity and specificity of P40 for the SQC diagnosis were 100% while the sensitivity of TTF-1 for ADC diagnosis was 88.9% and specificity was 100%. CONCLUSION: P40 and TTF-1 can be used as a reliable minimalistic panel for accurate subtyping of NSCLC. | ||
| Keywords | ||
| thyroid transcription factor; expression | ||
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