Effect of diphenhydramine on the changes in cholinesterase activity and intestinal motility induced by imidocarb in chicks | ||
| Iraqi Journal of Veterinary Sciences | ||
| Article 2, Volume 26, Suppl. II - Serial Number 3, September 2012, Pages 47-53 PDF (253.78 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/ijvs.2020.166874 | ||
| Authors | ||
| N.K. Ibrahim; G.A. Faris | ||
| Department of Physiology Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| This study examines and evaluates the interaction between imidocarb and diphenhydramine on the level of cholinesterase activity and small intestinal transit (SIT) in chicks. Imidocarb at 45 mg/kg,s.c. significantly inhibited plasma and brain cholinesterases, 30 min after injection by 69 and 21%, respectively. Diphenhydramine at 5 mg/kg, s.c significantly inhibited plasma and brain cholinesterase by 29.7 and 35.7%, respectively and significantly decreased the inhibitory effect of imidocarb on plasma cholinesterase by 33.2%. Imidocarb at 40 mg/kg, s.c. significantly increased SIT 15 and 30 min after injection by 92, 100%, respectively. Diphenhydramine at 5 and 10 mg/kg, s.c., 15 min before imedocarb at 40mg/kg, s.c. significantly decreased SIT produced by imidocarb alone by 80.6 and 70.5 %, respectively and prevented the SIT when given immediately after imedocarb at 40 mg/kg, s.c. by 100%.The data revealed that diphenhydramine has a beneficial effect in controlling the SIT modulated by imidocarb in chicks and there was no adverse interaction between two drugs at the level of cholinesterase. | ||
|
Statistics Article View: 422 PDF Download: 291 |
||