Profile of patients with Multiple sclerosis in Mosul City | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosul Journal of Nursing (Print ISSN: 2311-8784 Online ISSN: 2663-0311) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Article 6, Volume 7, Issue 2, August 2019, Pages 120-125 PDF (851.86 K) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Document Type: Original Articles | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: 10.33899/mjn.2020.164352 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Authors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mohammed Saleh Mohammed; Ali Neamat Sulaiman Alallaf | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Neurologist / FICMS Neurology / Ibn Sena Teaching Hospital | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Abstract | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Background: This study was carried out to assess the prevalence of MS in Mosul City. Methods: A retrospective study was applied in Mosul City for the period between (2020-2000). MS patient’s outpatient of Ibn-Sina Teaching hospital in Mosul City. Assessment of MS status: for the assessment of MS status the Kurtzke EDSS was used. EDSS was based on ten scores (0-10) and categorized the MS severity into three-level; mild disability (EDSS, 0.0 to 3.5), moderate disability (EDSS, 4.0 to 6.5), and severe disability (EDSS, 7.0 to 9.5). Microsoft Excel file was used to analyzed the data, number, percentage, Mean and Standard deviation were computed to analyze all demographic and clinical variables. This study was approved by the Ethics Committee of the Mosul Health Directorate, at Mosul City –Iraq. Results: the study found that the mean age of patients (34.7) among men and (32.9) among women. The mean age at onset is (28.9) among men and 27.9 among women. In relation to family history, 89.8% of men and 93.9% of women don’t have a positive family history with MS. The majority of the patient have Relapsing-remitting. Conclusion: In conclusion, the prevalence of MS has been steadily rising in Mosul city over the past few decades. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Keywords | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
profile; Multiple sclerosis; Mosul | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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PROFILE OF PATIENTS WITH MULTIPLE SCLEROSIS IN MOSUL CITY
ABSTRACT Background: This study was carried out to assess the prevalence of MS in Mosul City. Methods: A retrospective study was applied in Mosul City for the period between (2020-2000). MS patient’s outpatient of Ibn-Sina Teaching hospital in Mosul City. Assessment of MS status: for the assessment of MS status the Kurtzke EDSS was used. EDSS was based on ten scores (0-10) and categorized the MS severity into three-level; mild disability (EDSS, 0.0 to 3.5), moderate disability (EDSS, 4.0 to 6.5), and severe disability (EDSS, 7.0 to 9.5). Microsoft Excel file was used to analyzed the data, number, percentage, Mean and Standard deviation were computed to analyze all demographic and clinical variables. This study was approved by the Ethics Committee of the Mosul Health Directorate, at Mosul City –Iraq. Results: the study found that the mean age of patients (34.7) among men and (32.9) among women. The mean age at onset is (28.9) among men and 27.9 among women. About family history, 89.8% of men and 93.9% of women don’t have a positive family history with MS. The majority of the patent have Relapsing-remitting. Conclusion: In conclusion, the prevalence of MS has been steadily rising in Mosul city over the past few decades. Keywords: Profile, Multiple Sclerosis, Mosul
INTRODUCTION
Globally, Multiple sclerosis (MS) is the common neurodegenerative an immune-mediated demyelinating disease among the young-adults people' central nervous system. (AlJumah et al., 2020). At the onset, most patients have the relapsing-remitting disease, which stereotypically is tracked by a secondary progressive course, while a minority of patients has a primary progressive course from onset (10%).(Etemadifar et al., 2020) About relapsing-remitting, , most patients between 20-40 years old, their first symptoms of MS.(El-Wahsh, Ballard, Kumfor, Bogaardt, & Disorders, 2020) MS a variety of diseases representing different processes which suggested by the clinical heterogeneity, as well as, the findings of different pathological patterns. (Polat Dunya et al., 2020) In the last decade, the association between risk of environmental factors, identification of new genetic factors, and increased understanding of the significance of gene-environment (GxE) interactions have led to more agreement. (Nazari, Shaygannejad, Sic-hani, Mansourian, & Hajhashemi, (2020) Patients with MS can impression of stigmatized whereby the individual keeps characteristics that are either internally or externally perceived to be inferior, thus resulting in devaluation, rejection or exclusion. This study was carried out to assess the prevalence of MS in Mosul City. METHODS: A retrospective study was applied in Mosul City for the period between (2020-2000). MS patient’s outpatient of Ibn-Sina Teaching hospital in Mosul City. The inclusion criteria: age of patients more than between (18 years), At least one year since diagnosed with MS. Patients who agree to participate in the study. an information sheet was used to collect the data that related to the patients like (age, gender, residency) and disease history (age of onset, family history. Assessment of MS status: for the assessment of MS status the Kurtzke EDSS (Ciotti et al., 2020) was used. EDSS was based on ten scores (0-10) and categorized the MS severity into three-level; mild disability (EDSS, 0.0 to 3.5), moderate disability (EDSS, 4.0 to 6.5), and severe disability (EDSS, 7.0 to 9.5). Microsoft Excel file was used to analyzed the data, number, percentage, Mean and Standard deviation were computed to analyze all demographic and clinical variables. RESULTS: The study found that the mean age of patients (34.7) among men and (32.9) among women. The mean age at onset is (28.9) among men and 27.9 among women. In relation to family history, 89.8% of men and 93.9% of women don’t have a positive family history with MS. The majority of the patent have Relapsing-remitting.
Table 1: Comparison of the clinical patterns and disability according to sex
DISCUSSION
CONCLUSION: In conclusion, the prevalence of MS has been steadily rising in Mosul city over the past few decades. The clinical phenotype of MS in Mosul City is similar to what has been described in the other countries except for earlier age at onset and a more aggressive clinical course leading to earlier disability.
REFERENCES
Aleyasin, H., Sarai, A., Alaedini, F., Ansarian, E., & Lotfi, J. (2002). Multiple sclerosis: A study of 318 Iranian cases. AlJumah, M., Bunyan, R., Al Otaibi, H., Al Towaijri, G., Karim, A., Al Malik, Y. Algahtani, H. J. B. n. (2020). Rising prevalence of multiple sclerosis in Saudi Arabia, a descriptive study. 20(1), 49. Ashtari, F., Shaygannejad, V., Farajzadegan, Z., & Amin, A. J. J. o. r. i. m. s. t. o. j. o. I. U. o. M. S. (2010). Does early-onset multiple sclerosis differ from adult-onset form in Iranian people. 15(2), 94. Baghbanian, S. M., Cheraghmakani, H., HabibiSaravi, R., Azar, A., & Ghasemihamedani, F. J. B. n. (2020). Does the multiple sclerosis (MS) map need to change again? An update of MS prevalence in Mazandaran province of Iran in 2018. 20(1), 1-7. Ciotti, J. R., Sanders, N., Salter, A., Berger, J. R., Cross, A. H., Chahin, S. J. M. S., & Disorders, R. (2020). Clinical instrument to retrospectively capture levels of EDSS. 39, 101884. Deiva, K., Huppke, P., Banwell, B., Chitnis, T., Gärtner, J., Krupp, L., . . . Psychiatry. (2020). Consistent control of disease activity with fingolimod versus IFN β-1a in paediatric-onset multiple sclerosis: further insights from PARADIGMS. 91(1), 58-66. El-Muzaini, H., Akhtar, S., & Alroughani, R. J. B. n. (2020). A matched case-control study of risk factors associated with multiple sclerosis in Kuwait. 20(1), 1-7. El-Wahsh, S., Ballard, K., Kumfor, F., Bogaardt, H. J. M. S., & Disorders, R. (2020). Prevalence of self-reported language impairment in multiple sclerosis and the association with health-related quality of life: An international survey study. 39, 101896. Etemadifar, M., Janghorbani, M., Shaygannejad, V., & Ashtari, F. J. N. (2006). Prevalence of multiple sclerosis in Isfahan, Iran. 27(1), 39-44. Etemadifar, M., Nikanpour, Y., Neshatfar, A., Mansourian, M., Fitzgerald, S. J. M. S., & Disorders, R. (2020). Incidence and prevalence of multiple sclerosis in persian gulf area: A systematic review and meta-analysis. 101959. Moradi, A., Naiini, M. R., Yazdanpanahi, N., Tabatabaeian, H., Nabatchian, F., Baghi, M., . . . Ghaedi, K. J. C. J. (2020). Evaluation of The Expression Levels of Three Long Non-Coding RNAs in Multiple Sclerosis. 22(2). Nabavi, S., Sh, P., & Ghassemi, H. J. T. U. M. J. T. P. (2006). Clinical Course and prognosis of 203 patients with MS in shahid Mostafa Khomeini Hospital, Tehran 2002. 64(7), 90-97. Nazari, F., Shaygannejad, V., Sichani, M. M., Mansourian, M., & Hajhashemi, V. J. B. n. (2020). The prevalence of lower urinary tract symptoms based on individual and clinical parameters in patients with multiple sclerosis. 20(1), 1-11. Polat Dunya, C., Tulek, Z., Uchiyama, T., Haslam, C., Panicker, J. N. J. N., & urodynamics. (2020). Systematic review of the prevalence, symptomatology and management options of sexual dysfunction in women with multiple sclerosis. 39(1), 83-95. Scalfari, A., Neuhaus, A., Degenhardt, A., Rice, G. P., Muraro, P. A., Daumer, M., & Ebers, G. C. J. B. (2010). The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability. 133(7), 1914-1929. Yamout, B. I., Assaad, W., Tamim, H., Mrabet, S., Goueider, R. J. M. S. J. E., Translational, & Clinical. (2020). Epidemiology and phenotypes of multiple sclerosis in the Middle East North Africa (MENA) region. 6(1), 2055217319841881.
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References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Aleyasin, H., Sarai, A., Alaedini, F., Ansarian, E., &Lotfi, J. (2002). Multiple sclerosis: A study of 318 Iranian cases.
AlJumah, M., Bunyan, R., Al Otaibi, H., Al Towaijri, G., Karim, A., Al Malik, Y., . . . Algahtani, H. J. B. n. (2020). Rising prevalence of multiple sclerosis in Saudi Arabia, a descriptive study.20(1), 49.
Ashtari, F., Shaygannejad, V., Farajzadegan, Z., & Amin, A. J. J. o. r. i. m. s. t. o. j. o. I. U. o. M. S. (2010). Does early-onset multiple sclerosis differ from adult-onset form in Iranian people.15(2), 94.
Baghbanian, S. M., Cheraghmakani, H., HabibiSaravi, R., Azar, A., & Ghasemihamedani, F. J. B. n. (2020). Does the multiple sclerosis (MS) map need to change again? An update of MS prevalence in Mazandaran province of Iran in 2018.20(1), 1-7.
Ciotti, J. R., Sanders, N., Salter, A., Berger, J. R., Cross, A. H., Chahin, S. J. M. S., & Disorders, R. (2020). Clinical instrument to retrospectively capture levels of EDSS.39, 101884.
Deiva, K., Huppke, P., Banwell, B., Chitnis, T., Gärtner, J., Krupp, L., Psychiatry. (2020). Consistent control of disease activity with fingolimod versus IFN β-1a in paediatric-onset multiple sclerosis: further insights from PARADIGMS.91(1), 58-66.
El-Muzaini, H., Akhtar, S., & Alroughani, R. J. B. n. (2020). A matched case-control study of risk factors associated with multiple sclerosis in Kuwait.20(1), 1-7.
El-Wahsh, S., Ballard, K., Kumfor, F., Bogaardt, H. J. M. S., & Disorders, R. (2020). Prevalence of self-reported language impairment in multiple sclerosis and the association with health-related quality of life: An international survey study.39, 101896.
Etemadifar, M., Janghorbani, M., Shaygannejad, V., & Ashtari, F. J. N. (2006). Prevalence of multiple sclerosis in Isfahan, Iran.27(1), 39-44.
Etemadifar, M., Nikanpour, Y., Neshatfar,A., Mansourian, M., Fitzgerald, S. J. M. S., & Disorders, R. (2020). Incidence and prevalence of multiple sclerosis in persian gulf area: A systematic review and meta-analysis. 101959.
Moradi, A., Naiini, M. R., Yazdanpanahi, N., Tabatabaeian, H., Nabatchian, F., Baghi, M., . . . Ghaedi, K. J. C. J. (2020). Evaluation of The Expression Levels of Three Long Non-Coding RNAs in Multiple Sclerosis.22(2).
Nabavi, S., Sh, P., & Ghassemi, H. J. T. U. M. J. T. P. (2006). Clinical Course and prognosis of 203 patients with MS in shahid Mostafa Khomeini Hospital, Tehran 2002.64(7), 90-97. Nazari, F., Shaygannejad, V., Sichani, M. M., Mansourian, M., & Hajhashemi, V. J. B. n. (2020). The prevalence of lower urinary tract symptoms based on individual and clinical parameters in patients with multiple sclerosis.20(1), 1-11.
Polat Dunya, C., Tulek, Z., Uchiyama, T., Haslam, C., Panicker, J. N. J. N., & urodynamics. (2020). Systematic review of the prevalence, symptomatology and management options of sexual dysfunction in women with multiple sclerosis.39(1), 83-95.
Scalfari, A., Neuhaus, A., Degenhardt, A., Rice, G. P., Muraro, P. A., Daumer, M., & Ebers, G. C. J. B. (2010). The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability.133(7), 1914-1929.
Yamout, B. I., Assaad, W., Tamim, H., Mrabet, S., Goueider, R. J. M. S. J. E., Translational, & Clinical. (2020). Epidemiology and phenotypes of multiple sclerosis in the Middle East North Africa (MENA) region.6(1), 2055217319841881. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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