Synthesis and Identification of Some New Thiazole Derivatives which Derived from Pyrazoline Compounds and Evaluation the Antibacterial Activity of Some of them | ||
Kirkuk Journal of Science | ||
Article 1, Volume 14, Issue 4, December 2019, Pages 46-62 PDF (0 K) | ||
Document Type: Research Paper | ||
DOI: 10.32894/kujss.2019.14.4.4 | ||
Authors | ||
Ahmed A. H. Al-kadhimi1; Mohsin Omar Mohammed2; Ghazwan Thamir Qasim* 2 | ||
1Department of Chemistry, College of Science, Kirkuk University, Kirkuk, Iraq. | ||
2Department of Chemistry, Collage of Science, Kirkuk University, Kirkuk, Iraq. | ||
Abstract | ||
In this study some new derivatives of thiazole compounds were successfully prepared in two steps with high yields. The first step included a synthesis of a new series of pyrazoline (1a-1i) using a one-pot three components reaction. The reaction between (acetophenone4-nitroacetophenone), different substituted benzaldehyde compounds and thiosemicarbazide in absolute ethanol as a solvent with heating at reflux provided the new series of pyrazoline derivatives in a short reaction times. In the second step, the pyrazoline compounds (1a-1i) refluxed with 4-bromophenacyl bromide in absolute ethanol to produce thiazole compounds (2a-2i) in high yields. The Infra-red technique (FT-IR) was used to identify the synthesised compounds and the proton Nuclear Magnetic Resonance technique (1H-NMR) was used to identify som of them. . | ||
Keywords | ||
Thiazole; Pyrazoline; One; pot reaction; antibacterial activity | ||
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