The histological changes induced by cytarabine on rabbits kidneys (with and without vitamin E administration) | ||
| Iraqi Journal of Veterinary Sciences | ||
| Article 21, Volume 33, Issue 2, September 2019, Pages 311-316 PDF (1.5 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/ijvs.2019.162910 | ||
| Authors | ||
| Saif Al-Jammas* 1; ayad Al-Sarraj2 | ||
| 1College of Dentistry, University of Mosul, Mosul, Iraq | ||
| 2Dental Basic Sciences- College of Dentistry- University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| The present study was designed to determine the histological changes induced by Cytarabine drug on the structure of rabbits kidneys and the protective effects of vitamin E on these histological changes. The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone, showed a massive histological changes represented by renal tubular necrosis, glomerular atrophy and enlarged urinary spaces (widening of Bowman’s spaces), infiltration of lymphocytes and macrophages within interstitium of the cortex, formation of hyaline cast in some of the tubular lumens as well as fibrosis and hemorrhage in the cortex were also observed. While the group that received a protective (800 IU of vitamin E) prior to each Cytarabine injection showed a significant improvement that represented by focal regions in the cortex with a normal renal tubules except for a cloudy cell swelling which is a reversible injury, also neither cortical hemorrhage nor hyaline cast formation were seen, in addition to presence of focal areas of normal glomeruli. The present study suggests that vitamin E is an effective chemo-protective agent against nephrotoxicity when used prior to each Cytarabine administration. | ||
| Keywords | ||
| Cytarabine; Rabbit's kidney; vitamin E | ||
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