Spectrophotometric method for the determination of tolnaftate in pharmaceutical preparations | ||
| Journal of Education and Science | ||
| Article 4, Volume 27, Issue 1, January 2018, Pages 35-42 PDF (327.78 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/edusj.1970.161563 | ||
| Authors | ||
| Nief Rahman Ahmed* 1; Nawfal Sheet Mohamad2 | ||
| 1Department of Environmental Technology, College of Environment, University of Mosul, Mosul, Iraq | ||
| 2Department of Chemistry, College of Education, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| Abstract A simple, accurate, rapid and sensitive visible spectrophotometric method has been developed for the determination of tolnaftate in pure and pharmaceutical preparations. The method is based on the reaction of tolnaftate with potassium permanganate in alkaline medium to form a bluish green colored product with an absorption maximum at 610 nm. Beer’s law was obeyed in the range of 5-60 µg/25ml with a molar absorbitivity of 5.379×104 L.mol.-1.cm-1. The optimum conditions for all color development were described and the proposed method has been successfully applied for the determination of tolnaftate in pharmaceutical preparations. A statistical comparison of these results with those of official method using (t and F) values at 95% confidence level, The calculated t- and F- values did not exceed the theoretical values indicating that there was no significant differences between the precision of the proposed and official method. So that the proposed method can be used as a routine quality control for determination of tolnaftate in pure form and in pharmaceutical formulations.The common excipients and additives did not interfere in the proposed method. | ||
| Keywords | ||
| Tolnaftate; Potassium permangnate; Spectrophotometric | ||
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