Synthesis and Biological Activity of some New Nitrogenous Heterocyclic Compounds Derived from Azachalcone | ||
| Rafidain Journal of Science | ||
| Article 4, Volume 28, Issue 2, June 2019, Pages 37-46 PDF (192.36 K) | ||
| DOI: 10.33899/rjs.2019.159977 | ||
| Authors | ||
| Hamad J. Jumaa; Munera Y. Roof; Shakir M. Saied | ||
| Abstract | ||
| A series of heterocyclic compounds containing oxygen and nitrogen atoms, isoxazoline ІI(a-d) and another containing two nitrogen atoms, pyrazolinesІII(a-d) and phenylpyrazolines IV(a-d) were prepared by the reaction of a proper azachalcones І(a-d) with hydroxylaminehydrochloride, hydrazine hydrate or phenylhydrazine. These heterocyclic compounds were characterized by 1H-NMR , CHN , IR and UV spectra in addition to their some physical properties. Also, these prepared compounds were screened for their biological activities and a theoretical calculation which shows that the product IVa obtained from 1,2 – rout was energetically more stable by 1.3967 kcal/mole than that came from 1,4 – rout, thus the reaction proceed via 1,2 – addition 1,2)). | ||
| Keywords | ||
| azachalcone; isoxazoline; Pyrazoline; biological activity | ||
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