Protective effect of Silymarin against kidney injury induced by carbon tetrachloride in male rats | ||
| Iraqi Journal of Veterinary Sciences | ||
| Article 21, Volume 33, Issue 1, April 2019, Pages 127-130 PDF (756.38 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/ijvs.2019.125529.1051 | ||
| Authors | ||
| Measer Abdullah Ahmed* 1; Hussien Mohammad Tayawi2; Mohammed Khalil Ibrahim2 | ||
| 1Department of Biology, College of education for pure science, Tikrit university , Iraq. | ||
| 2Department of Biology, College of Education for Pure Science, Tikrit university, Tikrit - Iraq | ||
| Abstract | ||
| The herbal drugs have a protective effect for kidney function against chemical toxicity. 24 male rats divided into 4 groups and treated as following, control group administrated orally with 1ml/kg. B.W physiological solution (0.9%), One dose Carbon Tetrachloride (CCl4) 3 ml/kg. B.W, Silymarin 150 mg/kg. B.W and Silymarin150 mg/kg. B.W with CCl4 3 ml/kg. B.W for 30 days. Oxidative stress resulted by CCl4 caused increasing in Creatinine, Urea, total protein, Albumin, malondialdehyde (MDA) levels decreasing in Glutathione (GSH) and superoxide dismutase (SOD) levels in serum and congestion, degeneration and desquamation in kidney tissue. We concluded that Silymarin showed protective effect via increasing GSH, decreasing creatinine, Urea, total protein and MDA levels in serum and protect kidney tissue in rats. | ||
| Keywords | ||
| Silymarin; CCl4; Kidney toxicity; Antioxidant | ||
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