A Creative Indirect Spectrophotometric Determination of Naproxen | ||
| Rafidain Journal of Science | ||
| Article 7, Volume 28, Issue 1, March 2019, Pages 51-60 PDF (124.35 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/rjs.2019.159393 | ||
| Authors | ||
| Hana Sh. Mahmood; Thura Z. Al-Sarraj | ||
| Abstract | ||
| A New, sensitive spectrophotometric method for determination of Naproxen (Nap) has been proposed. The method is based on a modification of Naproxen into a hydroxy analog (mNap). The modified compound is coupled with the diazotized p-aminobenzoic acid (PABA) in alkaline medium, the resulting orange azo dye exhibit a maximum absorption at 500 nm. Beer's law is obeyed over the concentration range from 10 to 650 µg/20 ml, (i.e. 0.5-32.5 µg/ ml) with a good sensitivity (molar absorptivity 2.14x104 l.mol-1.cm-1), good precision (RSD% better than ±1.93%) and high accuracy (relative error % better than 0.43%), Sandell's sensitivity index is 0.0107µg.cm-2 and the limit of detection (LOD) is 0.024 µg/ml and the limit of quantitation (LOQ) is 0.082 µg/ml. The method has been applied successfully for determination of Naproxen in dosage forms after extraction of the active ingredient. . | ||
| Keywords | ||
| naproxen; Spectrophotometric; modification reaction; diazotized p; aminobenzoic acid; extraction; Creative | ||
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