Cross Malformations and Histolgical Changes in Liver of Pregnant Mice and their Embryos Exposed to Glue Smoke | ||
| Rafidain Journal of Science | ||
| Article 46, Volume 27, Issue 4, December 2018, Pages 354-373 PDF (809.8 K) | ||
| DOI: 10.33899/rjs.2018.159368 | ||
| Authors | ||
| Rayya Gh. Al-Sultan; Hafidh I. Al-Sadi; Hani M. Al-Hmadani | ||
| Abstract | ||
| This study was carried out to investigate the pathological and teratogenic change and histological effects to glue sniffing on liver of pregnant mice and their embryos. Mice were exposed to concentration of Glue smoke including (1500, 2500 and 3500) mg/kg-1 b.w., from the 7th to the18th day of pregnancy . Concentration of 2500 and 3500 mg/kg-1 b.w. were characterized by constant irritability, irregular movements and hyperactivity, for half an hour followed by sluggishness, sluggishness and little intake of food and water for several hours. As well as cases of 15% at the dose of 2500 and 40% at the dose 3500 mg/kg-1 b.w. and the loss of mice and by 13 and 20%, respectively, while the proportion of embryos distorted 34% and 65% and 80% at the concentration of 1500 and 2500 and 3500 mg/kg-1 b.w., respectively the emergence of embryonic and growth-free embryos, cerebral meningitis and head disfigurement with a bird-like end, swelling of facial and nasal features, graves of eye or eye loss, skin, trunk, limbs and tail abnormalities. Histopathological changes in pregnant mice were liver congestion hemorrhage, lipid aggregation between lobules and liver gain have a walnut-like appearance. Microscopic hemorrhagic bleeding, vacuolar degeneration, hepatic cell, and focal infiltration of inflammatory cells around blood vessels and bile ducts were observed in the portal area. The histopathological changes in maternal fetuses were hemorrhagic, blood vessel congestion, in filtration of inflammatory cells, expansion of sinusoids, vacuolar degeneration,coagulative necrosis of hepatic cells and arrhgthmia of liver cells.. | ||
| Keywords | ||
| Histolgical Changes; Malformations; Glue smoke; Liver | ||
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