SYNTHESIS A NUMBER OF AZO COMPOUNDS DERIVED FROM GUANINE AND STUDYING THEIR BIOLOGICAL ACTIVITY ON PATHOGENIC BACTERIA | ||
Journal of University of Anbar for Pure Science | ||
Article 9, Volume 2, Issue 3, December 2008, Pages 38-45 PDF (486.6 K) | ||
Document Type: Research Paper | ||
DOI: 10.37652/juaps.2008.15646 | ||
Author | ||
Yousif H. Khalaf* | ||
College of science / University of Anbar | ||
Abstract | ||
ABSTRACT: A series of compounds were prepared by coupling dizonium salts with guanine. The structures of the prepared compounds were identified by ultra violet ,infra red spectra and Elemental (C.H.N) analysis .The biological activity of these compounds was investigated on five genera of pathogenic bacteria: S. aureus , Str. viridans , Ps. aeruginosa , E. coli and Sh. dysenteriae using Disc diffusion method. Also the minimum inhibitory concentration (MIC) was calculated .It was found that these compounds have medium biological effect against these genera of bacteri Key words : Synthesis , Azo Compounds , Guanine and , Biological Activity , Bacteria | ||
Keywords | ||
synthesis; Azo Compounds; Guanine and; biological activity; bacteria | ||
References | ||
[1] C. M. Firo kapadia and H. D. Joshi (1996) J. of Chem., 35A, 884.
[2] A. C. Sartorelli, K. C. Agrawal and E. C. Moore (1971) Biochem. Pharmaco. 20, 3199.
[3] V. Betiana, (1983)“The Chemistry and Biology of Antibiotic”, Elsevier Scientific Publishing
Comp. Amsterdam. 283.
[4] Wilson and Givolds. (1988) Text Book of Organic Medical and Pharmaceutical Chemistry 10th ed.
[5] Franklin and Snow. (1987) “Biochemistry of Antimicrobial Action”, 4th ed. 106.
[6] F. Rafii and C. Cernigli. (1995) Environ – Health – perspect, 103 Suppl 5, 17- 9.
[7] B. Elliott, R. Jackh and R. Jung, Mutagenesis. (1994) 9(6), 517.
[8] A. Kalski, H. Strozynski and W. Smok. (1994) Med-Pr. 45(2), 107.
[9] G.E.wright. (1996) acta Biochem. Pol., 43,115.
[10] R.O.Roblin et al. (1945) J.Am.Chem.soc.,67,290.
[11] J.Aubercht, M.E.P.Goad and R.H.Schistl. (1997) . Pharmacology, 282,12,1102.
[12]M.J.Robins,P.W.Hatfield,J.Balzarrini and E.D.Clercq. (1984) . J.Med. Chem.,27,1486.
[13] B.A.Chabner. (1988) . J.Nation Cancer Institute., 80,No. 19,1512.
[14] M.Hocek. (2005) . Nucleic Acids symposium series, No. 49,29.
[15]M.K.Lakshman.(2002)J.Organomet.Chem.,653,234,.M.Hocek,Eur.(2003).J.Org.Chem.,2,25
[16] H.W.Seely,Jr., P.J.Vandemark. (1981)“Microbes in Action”, 3rd. ed.,W. H. Freedman and Comp. 178.
[17] R. M. Silverstein, G. C. Bassler and T.C. Morrill. (1988). “Spectrometric Identification of Organic Compounds”, 4th. ed., John Wiley and Son New York .
[18] R. L. Pecsok and Shields. (1988). “Modern Methods of Chemical Analysis”, 2nd ed. (Arabic
Translation) M. A. Mahdi, Mellitary Engineering College.
[19] W. Kemp. (1975). “Organic Spectroscopy”, The macmillan Press LTD 47.
[20] M. Siroki.(1971) . J. Less – common metals, 25, 431.
[21] L. J. Bellamy. (1975). “The Infrared Spectra of Complex Molecules”, Printed in Great Britain By Low. Brydon, LTD.
[22] K. Luttke and W. Zeit. (1960). Electro Chem., 64, 650.
[23] K. Ueno.(1957). J. Amer. Chem. Soc., 79, 3066.
[24] D. J. Hadzi. (1956). J. Chem. Soc., 2143. | ||
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