Synthesis a Number of Triazene Compounds Derived From Purine and Studying their Biological Activity on Pathogenic Bacteria | ||
| Journal of University of Anbar for Pure Science | ||
| Article 18, Volume 3, Issue 1, April 2009, Pages 59-65 PDF (419.33 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2009.15509 | ||
| Authors | ||
| Ahmed .M. Mohamed* ; Hameed H.Ali; Yousif. H. Khalaf | ||
| University of Anbar. College of science | ||
| Abstract | ||
| In this research a number of compounds were prepared by coupling dizonium salts with purine bases. The structures of the prepared compounds were identified by ultra violet ,infra red spectra and Elemental (C.H.N) analysis .The biological activity of these compounds was investigated on five genera of pathogenic bacteria: S. aureus , Str. viridans , Ps. aeruginosa , E. coli and Sh. dysenteriae using Disc diffusion method. Also the minimum inhibitory concentration (MIC) was calculated .It was found that these compounds have medium biological effect against these genera of bacteria. | ||
| Keywords | ||
| synthesis; Triazene; Purine; biological activity; bacteria | ||
| References | ||
|
[1] H.A.JSchoutissen. (1933). J.Am.Chem.Soc., 55, 4531.
[2] C.Milt and G.V.Zandt. (1936). J.Am. Chem. Soc., 58, 2044.
[3] O.S.Roudestvedt and S.J.Davis. (1957). J.Org. Chem., 22, 200
[4] G.J.Hatteway, C.Hansch, K.H.Kim, C.L.Sehnlidt, R.N.Smith and F.R.Quinn. (1978). J.Med. Chem.,21 , 563.
[5] Y.F.Shealy, C.A.Krauth and J.A.Mongomery. (1962). J.Org. Chem, 27, 2150.
[6] Y.F.Shealy.(1970). J.Pharm. Sci., 59., 1550.
[7] A.J.Lin and T.L.Loo. (1978). J. Med. Chem., 21, 268.
[8] J.L.Skibba, and G.T.Bryan. (1971). Toxicol, Appl. Pharmacol., 18, 707.
[9] J.L.Skibba, D.D Beal, G.Ramircz and G.R.Bryan. (1970). Cancer, Res. 30, 147.
[10] A.Mairuf. (1985). Msc. Thesis, Univesity of Baghdad, Iraq, Chap 3.
[11] H.Rosenmeyer. (2004).Chem. Biodiversity, 1, 361.
[12] B.A.Chabner. (1988). J. Nation Cancer Institute., 80, No. 19, 1512.
[13] Y.T.Chang, N.S.gray, , and others. (1999). Chemistry and biology, 6, No. 6, 362.
[14] P.Kramata, K.M.Downey. (1999). Mol. Pharmacol., 56, 1262.
[15] E.De. Clercq. (1991). Biochem.Pharmacol., 42, 963.
[16] M.K.Lakshman. (2002). J.Organomet.Chem., 653 , 234; M.Hocek, Eur. (2003).J.Org.Chem., 2, 245.
[17] H.W.Seely, Jr., P.J.Vandemark. (1981). "Microbes in action" 3rd ed., W.H.Freedman and Comp. 178.
[18] R.H.Sprague (to Horizonsinc) (1960). U.S.Z., 940, 979, June 14, (1960).C.A.54, 22685i.
[19] Z.M.Hussen, (1997). J.of Al-Anbar University No (1).
[20] R. L. Pecsok and Shields. (1988). “Modern Methods of Chemical Analysis”, 2nd ed. (Arabic Translation) M. A. Mahdi, Mellitary Engineering College.
[21] W. Kemp. (1975). “Organic Spectroscopy”, The macmillan Press LTD 47.
[22] M. Siroki.(1971) . J. Less – common metals, 25, 431.
[23] A.Quim. (1981). Ser B, 77. C.A. (1982). 96, 210435d.[24] D.J.Hadzi. (1956) J.Chem.Soc. 2143. | ||
|
Statistics Article View: 139 PDF Download: 121 |
||