Rashed, R., H. Ali, H. (2012). Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro). Alustath, 3(1), 57-63. doi: 10.37652/juaps.2009.15482
RashedM. Rashed; Hammed H. Ali. "Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro)". Alustath, 3, 1, 2012, 57-63. doi: 10.37652/juaps.2009.15482
Rashed, R., H. Ali, H. (2012). 'Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro)', Alustath, 3(1), pp. 57-63. doi: 10.37652/juaps.2009.15482
Rashed, R., H. Ali, H. Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro). Alustath, 2012; 3(1): 57-63. doi: 10.37652/juaps.2009.15482

Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro)

Journal of University of Anbar for Pure Science
Article 17, Volume 3, Issue 1, April 2009, Pages 57-63    PDF (422.57 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2009.15482
Authors
RashedM. Rashed* ; Hammed H. Ali
Anbar University - College of Science
Abstract
he present paper included a study of the inhibitory effect of three pyrimidine derivatives (6-amino
1,3dimethyl uracil (6-admu), 2'-deoxythmidine (dthy) and 6-(phenylazo)-cytidine (phazocyt)) in comparison with
the medical compound (6-MP) as a standard anti cancer on the inhibition of the growth of cancer cell line of Hep-2
(Human epidermoid larynx carcinoma) In vitro. Results have shown significant differences of a probability level
(p<0.001), compared with 6-MP compound of (phazocyt and 6-admu), while (dthy) compound did not show any
significant differences at the same level of probability (p>0.001). When comparing the inhibitory effect of
concentrations within the single compound, we notice significant differences of the probability level (p<0.001),
starting from the first treatment (62.5mg/ml) of (dthy) and (phazocyt) compounds. (6-admu) compound showed a
significant effect in the last treatment. Result have revealed that the two compounds (dthy, phazocyt) have greater
effect in comparison with 6-MP compound within (125mg/ml) concentration. Also, values of lethal inhibition
concentration of (IC50) and lethal concentration of 90% of cells (IC90) were extracted. It has been found that the
best activity was for (dthy) compound.
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