SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME OXAZEPINE AND OXAZINANE DERIVATIVES FROM REACTION OF SCHIFF BASES WITH SOME CYCLO ANHYDRIDE . | ||
| Journal of University of Anbar for Pure Science | ||
| Article 11, Volume 1, Issue 2, August 2007, Pages 47-61 PDF (715.57 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2007.15287 | ||
| Authors | ||
| WALEED F. AL-HITY1; MOHAMMED A.AL-HADITHI* 2; KAISS R.IBRAHEEM2 | ||
| 1Chem.Dept.College of Education for women, University of Al-Anbar | ||
| 2Chem.Dept.College of Science, University of Al-Anbar | ||
| Abstract | ||
| Schiff bases [2-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylimino)-5,5-diethyl-dihydro-pyrimidine-4,6-dione and 2,6-Bis-(1,5 Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylimino)-5,5-diethyl-tetrahydro-pyrimidin-4-one] were prepared by condensation of 5,5-Diethyl-pyrimidine-2,4,6-trione with one equivalent and tow equivalent of 4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one in ethanol (as solvent). These Schiff-base were reacted with one equivalent of maleic , succinic and malonic anhydride in absolute ethanol to give 7-membered heterocyclic ring system 12(1,5-Dimethyl -3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3,3-diethyl-7-oxa-1,5,12-triaza-spiro[5.6]dodecane-2,4,8,11-tetraone. and 6- membered heterocyclic ring system of 5-(1,5-Dimethyl -3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-9,9-diethyl-1-oxa-5,7,11-triaza-spiro[5.5] undecane-2,4,8,10-tetraone.Than , the product were reacted with tow equivalent of maleic , succinic and malonic anhydride in same solvent give 2 (7-membered) heterocyclic ring system of 8,15-Bis-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-18,18-diethyl-1,10-dioxa-6,8,15,16-tetraza-dispiro[6.1.6.3]octadeca-3,12-diene-2,5,11,14,17-pentaone.(9) and 2 (6-membered) heterocyclic ring system of 7,13-Bis-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-16,16-diethyl-1,9-dioxa-5,7,13,14-tetraza-dispiro[5.1.5.3]hexadecane-2,4,12,15-pentaone. The final organic products were identified by there m.ps, elemental analyses,IR, and UV-Visible spectra. | ||
| Keywords | ||
| synthesis; Characterization; oxazepine; oxazepane; biological activity | ||
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