RELATIONSHIP BETWEEN AGE AND SERUM ANTI-MULLERIAN HORMONE IN FERTILE AND SUBFERTILE FEMALES | ||
| Duhok Medical Journal | ||
| Article 13, Volume 10, Issue 1, November 2016, Pages 13-13 | ||
| Authors | ||
| BAYBEEN K. AL-SELEVANY1; MANAR G. SABBAGHA2 | ||
| 1Assistant Professor, Acting dean, Mosul College of Medicine, University of Mosul | ||
| 2Master student, Department of Physiology, Neinawa College of Medicine, University of Mosul | ||
| Abstract | ||
| Background and aim: Infertility is a common problem in our society ,female fertility declines with age due to decrease in the number of growing ovarian follicles. Anti-Mullerian hormone, is a glycoprotein produced in the ovaries by the granulosa cells of ovarian follicles, maily in preantral and small antral stages. The aim of this study is to measure the level of serum Anti-mullerian hormone in both fertile and subfertile females of the same age group (20-40)years and to find whether Anti-Mullerian hormone level changes with age and to compare its level between the two groups and their age subgroups ,this could be useful to evaluate ovarian reserve and female fertility. Methods: A case control study was conducted on 130 females ,70 (53.84%) subfertile females (patients) with a mean± SD 28.75±6.76 years and 60(46.15%) fertile female (controls) with a mean ± SD 31.26±5.98 years ,in Mosul city / fertility and IVF center in Al- Batool Teaching Hospital during the period from 1st of November 2013 to 30th of April 2014 . Serum Anti-Mullerian hormone concentration was measured in both patients and controls. Results: In this study, there was a significant negative correlation between serum concentration of Anti-Mullerian hormone and age. The Anti- Mullerian hormone level was inversely correlate with the age of whole sample (r=-0.53), age of subfertile females (r=- 0.50) and age of fertile females (r=-0.73).The serum Anti-Mullerian hormone level of subfertile females was significantly lower than its level in fertile females (p=0.006), a significant higher Anti-Mullerian hormone in fertile younger and older females in comparison to subfertile females (p=0.001 and p=0.006 respectively ) ; a significant decrease in Anti-Mullerian hormone after the age of 30 years in both fertile and subfertile females ( p=0.0001). Conclusions: The present study , concluded that there was a significant negative correlation between serum Anti-Mullerian hormone and age ,a decline in Anti-Mullerian hormone level with increasing age in both fertile and subfertile females and its level can be considered a useful test to predict ovarian reserve in females, and should be done routinely . | ||
| Keywords | ||
| Age; Anti-mullerian hormone; Fertile and subfertile females | ||
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