ASSESSMENT OF SERUM HOMOCYSTEINE LEVEL IN PATIENTS WITH MISSED MISCARRIAGE | ||
| Duhok Medical Journal | ||
| Article 7, Volume 10, Issue 1, November 2016, Pages 7-7 | ||
| Authors | ||
| QASIM H. ABDULLAH1; SHEREEN. A. IBRAHIM2; HANAA DANYAL ORAHAM3 | ||
| 1Professor., Department of Physiology, and the Dean, College of Medicine, University of Duhok | ||
| 2Lecturer, Department, of Physiology, College of Medicine, University of Duhok | ||
| 3Directorate of Preventive Health Affairs, Duhok Health General Dentist, Directorate | ||
| Abstract | ||
| Background and Objective: Accumulative reports documented that homocysteine (hcy) was implicated in many diseases. In recurrent missed miscarriage, the reports are limited and scarce. The objective was to evaluate the effect of hyperhomocysteinemia in the etiology of recurrent missed miscarriage. Methods: This study involved sixty seven patients with confirmed diagnosis of missed miscarriage. The second group served as control group and included ninety four ladies subdivided into three subgroups: a) Thirty five normal pregnant ladies with matched gestational age’ .b) Twenty nine apparently healthy non-pregnant ladies with matched age. c) Thirty apparently healthy full term pregnant ladies with matched age. The following main parameters were measured: Total serum homocysteine levels, Serum Human Chorionic Gonadotropin concentration(HCG), Serum progesterone concentration, complete blood count. Placental Histopathological Specimens Examination: Placental tissues were obtained from women after delivery and women with recurrent missed miscarriage and were examined histologically by using hematoxyline and eosin stain and also using CD34 immunohistochemistry. Results: Serum homocysteine in cases of single missed abortion was significantly higher compared to recurrent missed miscarriage cases, non-pregnant cases and pregnant with matched gestational age groups (13.1 VS 9.8, 8.5, 8.7µmol/L, P< 0.009). Serum Human Gonadotropin was significantly higher in pregnant controls compared to that of missed miscarriage groups( 10000 VS 2198.5 mlu/ml, P<0.001). Serum progesterone level was significantly higher in pregnant controls than recurrent missed miscarriage group (30.06 VS 3.64 ng/ml, P< 0.001). In missed miscarriage group, serum Hcy significantly negatively correlated with gravity and parity. Histopathological Results: There were histopathological changes of placental tissues of missed abortion cases in comparison to placenta of normal healthy fullterm pregnant cases including hyalinization of villi with focal or total losing of cytotrophoblast, hydropic degeneration, vasculitis of blood vessel and hemorrhage within decidua. Conclusion: Data of the present study demonstrated that elevated homocysteine level has an important role in the pathogenesis of missed miscarriage. | ||
| Keywords | ||
| Recurrent missed miscarriage; homocysteine | ||
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