Preparation and Characterization of Domperidone Nanoparticles for Dissolution Improvement | ||
| Iraqi Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 27, Issue 1, December 2018, Pages 39-52 | ||
| Authors | ||
| Mohammed S. Al-lami; Firas A. Rahi; Malath H. Oudah | ||
| Abstract | ||
| This study was carried out to prepare and characterize domperidone nanoparticles to enhance solubility and the release rate. Domperidone is practically insoluble in water and has low erratic bioavailability range from 13%-17%. The domperidone nanoparticles were prepared by solvent/antisolvent precipitation method at different polymer:drug ratios of 1:1 and 2:1 using different polymers and grades of poly vinyl pyrolidone, hydroxy propyl methyl cellulose and sodium carboxymethyl cellulose as stabilizers. The effect of polymer type, ratio of polymer:drug, solvent:antisolvent ratio, stirring rate and stirring time on the particle size, were investigated and found to have a significant (p≤ 0.05) effect on particle size. The best formula was obtained with lowest average particle size of 84.05nm, which composed from 2:1 of PVP-K15:drug and solvent/antisolvent volume ratio of 1:10. This formula was freeze dried and studied for compatibility by FTIR and DSC, surface morphology by Field Emission Scanning Electron Microscope (FESEM) and crystalline state by XRPD. Then domperidone nanoparticles were formulated into a simple capsule dosage form in order to study of the in vitro release of drug from nanoparticles in comparison pure drug and mixture of polymer:drug ratios of 2:1. The release of domperidone from best formula was highly improved with a significant (p≤ 0.05) increase. it can conclude that nanoparticles showed better in vitro dissolution profiles in comparison with pure drug | ||
| Keywords | ||
| Domperidone; Solvent; Polymers; Polyvinyl pyrrolidone; Nanoparticles; Dissolution rate; Release | ||
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