Association of HLA class I -A and B alleles with hydatidosis In Iraqi patients | ||
| Almuthanna Journal of Pure Science (MJPS) | ||
| Article 1, Volume 2, Issue 1, December 2014, Pages 0-0 | ||
| Authors | ||
| Batool Al-Ghurabi; Lazim Hammed; Samir Sabaa | ||
| Abstract | ||
| Hydatidosis is a parasitic disease caused by infection with larval stage of cestode worm Echinococcus granulosus ,it is a worle_wide disease results in serious health and financial loss. Iraq considered as an endemic region for this disease. the association of HLA –alleles frequency with the occurrence of various diseases were studied . and significant associations were found, no sufficient studies on hydatidosis and possible role of HLA typing and the immune status of the patients and association of them with cyst characteristics ,and cytokines profile and their effect on production of immunoglobulin . blood samples were collected for extraction of DNA and amplification by (PCR-SSO) and HLA typing by Automatic Line Probe Assay (Auto-Lipa) for HLA typing of both patients and healthy control groups, to study the association of certain HLA alleles. With occurrence of Hydatid disease. The present study reported increase in frequency of HLA-A*0273 in hydatid patients compare to healthy control . | ||
| Keywords | ||
| HLA; alleles; Hydatidosis; PCR | ||
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