ROLE OF IMMUNOLOGICAL MARKERS IN CERTAIN GASTROENTEROLOGICAL DISORDERS | ||
| AL-TAQANI | ||
| Article 1, Volume 27, Issue 2, April 2014, Pages 0-0 | ||
| Authors | ||
| Midean A. Hussein; Ahmed H. Merdas; Mayada N. Iqbal | ||
| Abstract | ||
| Ulcerative colitis (UC) and celiac disease (CD) are autoimmune diseases. Perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) have been described in patients with inflammatory bowel disease, mainly ulcerative colitis. However, their role in pathogenesis and diagnostic value are still controversial. The aim of this study was to assess the prevalence of certain perinuclear anti-neutrophil cytoplasmic antibodies (p.ANCA) including anti-lactoferrin, anti-lysozyme and anti-elastase antibodies among patients with ulcerative colitis and celiac disease. This study was conducted during the period from August 2012 to January 2013. Subjects enrolled in this study were 34 ulcerative colitis patients (age range of 14-60 years with a mean of 31.29 years) and 34 celiac disease patients (age range of 12-58 years with a mean of 28.59 years). All patients were attending two Iraqi hospitals in Baghdad and Babylon cities who were subjected to endoscopic examination under the supervision of a gastroenterologist, for their primary diagnosis. The primary diagnosis was supported by serological examination for IgA /IgG tissue transglutaminase (tTG) for patients with celiac disease. Another 34 healthy subjects who were matching the patients groups in their age range and mean, were also enrolled in this study as a negative control group. Male to female ratios were approximately similar in all study groups. | ||
| Keywords | ||
| ROLE OF IMMUNOLOGICAL MARKERS IN CERTAIN GASTROENTEROLOGICAL DISORDERS | ||
|
Statistics Article View: 188 PDF Download: 104 |
||