IMMUNOLOGICAL DIAGNOSIS OF CELIAC DISEASE IN SYMPTOMATIC CHILDREN IN KIRKUK GOVERNORATE | ||
| AL-TAQANI | ||
| Article 1, Volume 27, Issue 2, April 2014, Pages 0-0 | ||
| Authors | ||
| Adnan H. Jawad; Farhan A. Risan; Braihan H. Hameed | ||
| Abstract | ||
| The aim of the present study is to estimate the occurrence of the celiac disease among clinically suspected children using immunoglobulin antibodies against gliadin (IgA and IgG-AGA) and against human tissue transglutaminase (IgA and IgG-tTG) as screening method. The study included 60 children with signs and symptoms suggested to have celiac disease (average age 36 months) who attended the Children's Hospital/ Kirkuk during the period from November/ 2011 until March/ 2012 and 30 apparently healthy children (average age 45 months) were chosen as a control group. Negative results were obtained in 33 (55.0%) clinically suspected children and 30 (100%) of control children. Positive results included antigliadin antibodies (IgA-AGA and IgGAGA or both) in 27 (45.0%) patients and tissue transglutaminase (IgA-tTG and IgGtTG or both) in 10 (16.6%) patients. The biopsy of five children were positive for both AGA (IgA and IgG) and tTG (IgA and IgG) revealed that characteristic lesions of celiac disease. It can be concluded that among the 60 patients that were tested, positive results of AGA (IgA and IgG) and tTG (IgA and IgG) represented (13.3%) and (11.7%) respectively and (8.3%) were confirmed by biopsy. | ||
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