IN SITU HYBRIDIZATION APPROACH FOR DETECTION OF EPSTEIN –BARR VIRUS & HUMAN PAPILLOMAVIRUS TYPE 16 IN A GROUP OF IRAQI WOMEN WITH CERVICAL CARCINOMA | ||
| AL-TAQANI | ||
| Article 1, Volume 27, Issue 2, April 2014, Pages 0-0 | ||
| Authors | ||
| Jasim Mohammed Muhsin; Ban A. Abdul-Majeed; Saja J. Al-Khalidi | ||
| Abstract | ||
| Aim: In order to investigate the involvement of (EBV & HPV 16) viruses in the pathogenesis of cervical carcinoma, the presence of the genome of these viruses were investigated in 100 cervical biopsies, histologically classified as squamous cell carcinomas & adenocarcinomas of uterine cervix. Methods: detection of DNA signals for both EBV & HPV 16 by non-radioactive In Situ Hybridization technique (ISH). Results: A different percentage of positively signals for vital infection was found between the two groups of examined DNA; EBV & HPV 16 infection in cervical carcinoma cases were 52% and 70% respectively; on the contrary in normal cervix tissues a low percentage of viral genomes presence were detected: 44% for EBV and 25% for HPV 16. Conclusions: The present study shows there is a compelling body of evidence that cervical carcinoma is related to human papilloma virus infection as a Co-factor and more recently Epstein- Barr virus have been proposed as candidates ( other Co-factore) for cervical neoplasia. Our data confirm the involvement of HPV16 & EBV in cervical neoplasia and suggest a possible role of these viruses in cervical cancerogenesis | ||
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